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370625 Guanabenz Acetate - CAS 23256-50-0 - Calbiochem

A cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells and acts as a proteostatis regulator.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(2,6-Dichlorobenzylideneamino)guanidine, Acetate, WY-8678

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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      23256-50-0C₈H₈Cl₂N₄ • C₂H₄O₂
      Description
      OverviewA cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells (EC50 ~ 400 nM in tunicamycin treated HeLa cells) and acts as a proteostatis regulator. Shown to selectively bind PPP1R15A/GADD34 and disrupt the PPP1R15A-PP1c complex; sustain eIF2α phosphorylation and increase chaperone availability by attenuating translation.
      Catalogue Number370625
      Brand Family Calbiochem®
      Synonyms1-(2,6-Dichlorobenzylideneamino)guanidine, Acetate, WY-8678
      References
      ReferencesTsaytler, P., et al. 2011. Science 332, 91.
      Erb, S., et al. 2000. Neuropsychopharmacology 23, 138,
      Handley, S.L. and Mithani, S., 1984. Naunyn Schmiedebergs Arch. Pharmacol. 327, 1.
      Product Information
      CAS number23256-50-0
      FormWhite powder
      Hill FormulaC₈H₈Cl₂N₄ • C₂H₄O₂
      Chemical formulaC₈H₈Cl₂N₄ • C₂H₄O₂
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      370625 0

      Documentation

      Guanabenz Acetate - CAS 23256-50-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Guanabenz Acetate - CAS 23256-50-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      370625

      References

      Reference overview
      Tsaytler, P., et al. 2011. Science 332, 91.
      Erb, S., et al. 2000. Neuropsychopharmacology 23, 138,
      Handley, S.L. and Mithani, S., 1984. Naunyn Schmiedebergs Arch. Pharmacol. 327, 1.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-August-2012 JSW
      Synonyms1-(2,6-Dichlorobenzylideneamino)guanidine, Acetate, WY-8678
      DescriptionA cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells (EC50 ~ 400 nM in tunicamycin treated HeLa cells) and acts as a proteostatis regulator. Shown to selectively bind PPP1R15A/GADD34 and disrupt the PPP1R15A-PP1c complex; sustain eIF2α phosphorylation and increase chaperone availability by attenuating translation.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number23256-50-0
      Chemical formulaC₈H₈Cl₂N₄ • C₂H₄O₂
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityH₂O (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesTsaytler, P., et al. 2011. Science 332, 91.
      Erb, S., et al. 2000. Neuropsychopharmacology 23, 138,
      Handley, S.L. and Mithani, S., 1984. Naunyn Schmiedebergs Arch. Pharmacol. 327, 1.