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TGFBMAG-64K-03 MILLIPLEX MAP TGFß Magnetic Bead 3 Plex Kit - Immunology Multiplex Assay

TGFBMAG-64K-03
96-well plate  
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      Overview

      Replacement Information

      Key Spec Table

      Analytes AvailableSpecies ReactivityKey ApplicationsDetection Methods
      TGF-β1, TGF-β2, TGF-β3H, M, R, NhP, Ca, Fe, Po, EqMplexLuminex xMAP
      Description
      Catalogue NumberTGFBMAG-64K-03
      Trade Name
      • MILLIPLEX
      DescriptionMILLIPLEX MAP TGFß Magnetic Bead 3 Plex Kit - Immunology Multiplex Assay
      Background InformationThe transforming growth factor beta (TGFβ) system, a superfamily of cytokines as well as signaling pathways, is highly conserved throughout the animal kingdom. TGFβ functions in immune cell development, angiogenesis, wound healing and embryonic development, bone development and plays a critical role in immune response, heart disease, and cancer. In its normal state TGFβ is one of the few classes of proteins able to inhibit cell growth by halting mitosis at the G1 state, inducing cell differentiation or apoptosis. However, during oncogenesis mutations in the TGFβ signaling pathway result in tumor cell resistance to the effects of normally functioning TGFβ, causing proliferation without regulation. Initial research suggests that VE-cadherin may enhance the mutated TGFβ signaling pathway.
      References
      Product Information
      Detection methodLuminex xMAP
      ConfigurationPremixed
      Precision, %
      • Inter-assay: < 10
      • Intra-assay: < 10
      Panel TypeMAGNETIC Cytokines/Chemokines
      Quality LevelMQ200
      Applications
      ApplicationThis MILLIPLEX MAP TGFß (Transforming Growth Factor Beta) - 3 Plex is an Immunology Multiplex Assay is used for the simultaneous quantification of TGFß1, TGFß2 and TGFß3 in the following species: Mouse/Human/Rat/Pig/Horse/Dog/Cat/Non-Human Primate.
      Key Applications
      • Multiplexing
      Application Notes• This is a 2-hour or overnight incubation assay.
      • This assay requires 25 μL of a 1:30 dilution after treatment of serum and plasma samples.
      • In addition to human, TGFβ1 was detected in acid-activated serum of every species tested which included horse, rabbit, mouse, rat, mini pig, canine, hamster, guinea pig, rhesus monkey and cynomolgous monkey. In addition to human, TGFβ2 was detected in the acid-activated serum of the following: horse, rabbit, mouse, rat, mini pig, canine, hamster, guinea pig, rhesus monkey and cynomolgous monkey. In addition to human, TGFβ3 was detected in mouse, rat, mini pig, hamster, guinea pig, rhesus monkey and cynomolgous monkey samples.

      However, the exact amount of cross reactivity has not been determined.
      Biological Information
      SpecificityCross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      • Non-human Primate
      • Canine
      • Feline
      • Pig
      • Horse
      Analytes Available
      • TGF-β1
      • TGF-β2
      • TGF-β3
      Assay PanelPremixed beads for your convenience.
      Accuracy
      • 62% - 128%
      Physicochemical Information
      Sensitivity
      • 8 - 12 pg/mL
      Standard Curve Range
      • 9.8 - 2,500 pg/mL
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsRecommended storage for kit components is 2 - 8°C.
      Packaging Information
      Material Size96-well plate
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Protocols

      Title
      Protocol: TGFβ 1,2,3 Magnetic Bead Kit

      MILLIPLEX MAP TGFß Magnetic Bead 3 Plex Kit - Immunology Multiplex Assay SDS

      Title

      Safety Data Sheet (SDS) 

      Brochure

      Title
      A closer look at immunoassay platforms. Beyond fit for purpse. Bring your biomarkers to life with Merck Millipore Immunoassay Platform Solutions.
      Analyte Quarterly Vol. 2 2020
      Custom Immunoassay Menu of Services
      The Power of Biomarker Analysis

      Technical Info

      Title
      96 well Template 2 Up
      96 well Template Single
      Quality Control Ranges - Milliplex® TGF-β1,2,3 Plex

      Data Sheet

      Title
      Full Service Custom-built Assays (Merck)

      Posters

      Title
      MILLIPLEX MAP: The Immunology of Cancer
      MILLIPLEX® MAP Cell Signaling Wall Chart (MM)