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550602 PKM2 Activator II, DASA - CAS 1186654-00-1 - Calbiochem

PKM2 Activator II, DASA, is a cell-permeable, potent, and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Pyruvate Kinase M2 Activator II, 1-(2,6-Difluorophenylsulfonyl)-4-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)piperazine

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550602
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1186654-00-1C₁₈H₁₈F₂N₂O₆S₂

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      Description
      OverviewA cell-permeable diarylsulfonamide (DASA) compound that acts as a potent and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM). Pretreatment of A549 (adenocarcinomic human alveolar basal epithelial cells) with DASA-10 (~10 µM) prevents hydrogen peroxide, diamide, and hypoxia-induced inactivation of PKM2. DASA treatment is shown to cause a diminution in cellular glutathione levels, and higher oxidative stress-induced cell death.
      Catalogue Number550602
      Brand Family Calbiochem®
      SynonymsPyruvate Kinase M2 Activator II, 1-(2,6-Difluorophenylsulfonyl)-4-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)piperazine
      References
      ReferencesAnastasiou, D., et al. 2011. Science 334, 1278.
      Boxer, M.B., et al. 2010. J. Med. Chem. 53, 1048.
      Product Information
      CAS number1186654-00-1
      FormWhite powder
      Hill FormulaC₁₈H₁₈F₂N₂O₆S₂
      Chemical formulaC₁₈H₁₈F₂N₂O₆S₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationPKM2 Activator II, DASA, is a cell-permeable, potent, and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM).
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      550602-10MG 04055977268874

      Documentation

      PKM2 Activator II, DASA - CAS 1186654-00-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PKM2 Activator II, DASA - CAS 1186654-00-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      550602

      References

      Reference overview
      Anastasiou, D., et al. 2011. Science 334, 1278.
      Boxer, M.B., et al. 2010. J. Med. Chem. 53, 1048.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-October-2012 JSW
      SynonymsPyruvate Kinase M2 Activator II, 1-(2,6-Difluorophenylsulfonyl)-4-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)piperazine
      DescriptionA cell-permeable diarylsulfonamide (DASA) compound that acts as a potent and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM). Pretreatment of A549 (adenocarcinomic human alveolar basal epithelial cells) with DASA-10 (~10 µM) prevents hydrogen peroxide, diamide, and hypoxia-induced inactivation of PKM2. DASA treatment is shown to cause a diminution in cellular glutathione levels, and higher oxidative stress-induced cell death.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1186654-00-1
      Chemical formulaC₁₈H₁₈F₂N₂O₆S₂
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesAnastasiou, D., et al. 2011. Science 334, 1278.
      Boxer, M.B., et al. 2010. J. Med. Chem. 53, 1048.