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526610 PlGF-1, Human, Recombinant, S. frugiperda

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Placenta Growth Factor-1

526610
  
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      Overview

      Replacement Information

      Key Spec Table

      Purity
      ≥90% by SDS-PAGE
      Description
      Overview

      This product has been discontinued.





      Recombinant, human PlGF-1 (a 131 amino acid splice variant of PlGF) expressed in S. frugiperda insect cells. A dimeric glycoprotein with a high degree of sequence homology to vascular endothelial growth factor (VEGF). Has been shown to antagonize VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PIGF-1/VEGF heterodimers. Forms a homodimer with some degree of heterogeneity due to differential glycosylation. Has also been shown to form a biologically active heterodimer with VEGF. Binds immobilized rh-sFlt-1 (100 ng/ml) in the range of 0.1-10 ng/ml.
      Catalogue Number526610
      Brand Family Calbiochem®
      SynonymsPlacenta Growth Factor-1
      References
      ReferencesEriksson, A., et al. 2002. Cancer Cell 1, 99.
      Khaliq, A., et al. 1999. Lab. Invest. 79, 151.
      Ziche, M., et al. 1997. Lab Invest. 76, 517.
      Birkenhager, R., et al. 1996. Biochem. J. 316, 703.
      Sawano, A., et al. 1996. Cell. Growth Differ. 7, 213.
      Park, J.E., et al. 1994. J. Biol. Chem. 269, 25646.
      Product Information
      FormLyophilized
      FormulationLyophilized from 50 mM acetic acid, BSA.
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥90% by SDS-PAGE
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      526610 0

      Documentation

      PlGF-1, Human, Recombinant, S. frugiperda SDS

      Title

      Safety Data Sheet (SDS) 

      PlGF-1, Human, Recombinant, S. frugiperda Certificates of Analysis

      TitleLot Number
      526610

      References

      Reference overview
      Eriksson, A., et al. 2002. Cancer Cell 1, 99.
      Khaliq, A., et al. 1999. Lab. Invest. 79, 151.
      Ziche, M., et al. 1997. Lab Invest. 76, 517.
      Birkenhager, R., et al. 1996. Biochem. J. 316, 703.
      Sawano, A., et al. 1996. Cell. Growth Differ. 7, 213.
      Park, J.E., et al. 1994. J. Biol. Chem. 269, 25646.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-June-2010 JSW
      SynonymsPlacenta Growth Factor-1
      DescriptionRecombinant, human PlGF-1 (a 131 amino acid splice variant of PlGF) expressed in S. frugiperda insect cells. Acts only as a weak mitogen for some endothelial cell types, but functions as a potent chemotactic agent for monocytes. Has been reported to be angiogenic in the CAM and rabbit cornea assays. Forms a homodimer with some degree of heterogeneity due to differential glycosylation. Has also been shown to form a biologically active heterodimer with VEGF. FLT-1 (VEGFR1) has been shown to be a high-affinity receptor for PIGF in several primary cell types; however, PIGF does not bind to KDR/flk-1 (VEGFR2). Binds immobilized rh-sFlt-1 (100 ng/ml) in the range of 0.1-10 ng/ml.
      FormLyophilized
      FormulationLyophilized from 50 mM acetic acid, BSA.
      Purity≥90% by SDS-PAGE
      SolubilityReconstitute in PBS or 100 mM acetic acid to a concentration ≥100 ng/µl.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
      Toxicity Standard Handling
      ReferencesEriksson, A., et al. 2002. Cancer Cell 1, 99.
      Khaliq, A., et al. 1999. Lab. Invest. 79, 151.
      Ziche, M., et al. 1997. Lab Invest. 76, 517.
      Birkenhager, R., et al. 1996. Biochem. J. 316, 703.
      Sawano, A., et al. 1996. Cell. Growth Differ. 7, 213.
      Park, J.E., et al. 1994. J. Biol. Chem. 269, 25646.