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855008 Sieber Amide resin

Novabiochem®

Sieber Amide resin MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 915706-90-0
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855008
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Overview

Replacement Information

Key Spec Table

CAS #
915706-90-0
Description
Catalogue Number855008
Replaces01-64-0059
Brand Family Novabiochem®
Alternate Names
  • 9-Fmoc-amino-xanthen-3-yloxy-Merrifield resin
Background InformationA hyper acid-labile linker for the Fmoc SPPS of protected peptide amides via mild 1% TFA cleavage [1, 2]. The resin can be readily reductively alkylated to provide a support suited to the synthesis of secondary carboxamides [3].

This resin has also been employed to produce protected peptide fragments in which the C-terminal carboxylic acid group is blocked as a hydroxymethylphenoxy-β-alaninamide ester [4].

The product number for this product was previously 01-64-0059.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
References
Product Information
CAS number915706-90-0
HS Code3903 90 90
Structure formula ImageStructure formula Image
Quality LevelMQ400
Applications
Biological Information
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Storage class10 - 13 Other liquids and solids
WGKWGK 1 slightly hazardous to water
Safety Information
Product Usage Statements
Storage and Shipping Information
StorageStore at +2°C to +8°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Color (visual)white to light yellow to beige
Appearance of substance (visual)beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF)0.60 - 0.90 mmol/g
Swelling Volume (in DMF)lot specific result
Swelling Volume (in CH₂Cl₂)lot specific result
Total swelling volume acc. Houben Weyl (in CH2Cl2)≥ 5.2 ml/g
Total swelling volume acc. Houben Weyl (in DMF)≥ 5.2 ml/g
The polymer matrix is copoly (styrene - 1% DVB) 100 -200 mesh

Documentation

Sieber Amide resin SDS

Title

Safety Data Sheet (SDS) 

Citations

Title
[1] P. Sieber (1987) Tetrahedron Lett., 28, 2107.
[2] C. Somlai, et al. in "Peptides 1992, Proc. 22nd European Peptide Symposium", C. H. Schneider & A. N. Eberle (Eds), 1993, pp. 198.
[3] W. C. Chan, et al. (1995) J. Chem. Soc., Chem. Commun., 1475.
[4] W. C. Chan, et al. (1995) J. Chem. Soc., Chem. Commun., 589.