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108219 Tris(hydroxymethyl)aminomethane hydrochloride

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MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Trometamol, Aminomethylidine trimethanol, 2-Amino-2-hydroxymethyl-1.3-propanediol, TRIS-buffer

CAS #: 1185-53-1 EC Number: 214-684-5 Molar Mass: 157.60 g/mol Chemical Formula: C₄H₁₁NO₃*ClH Hill Formula: C₄H₁₁NO₃˙ ClH
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Overview

Replacement Information

Key Spec Table

CAS #EC NumberHill FormulaChemical FormulaMolar Mass
1185-53-1214-684-5C₄H₁₁NO₃˙ ClHC₄H₁₁NO₃*ClH157.60 g/mol
Description
Catalogue Number108219
SynonymsTrometamol, Aminomethylidine trimethanol, 2-Amino-2-hydroxymethyl-1.3-propanediol, TRIS-buffer
DescriptionTris(hydroxymethyl)aminomethane hydrochloride
References
Product Information
CAS number1185-53-1
EC number214-684-5
Hill FormulaC₄H₁₁NO₃˙ ClH
Chemical formulaC₄H₁₁NO₃*ClH
Molar Mass157.60 g/mol
HS Code2922 19 99
Structure formula ImageStructure formula Image
Quality LevelMQ500
Applications
Biological Information
Physicochemical Information
Density1.28 g/cm3 (20.2 °C)
Melting Point150.7 °C
pH value4.2 (100 g/l, H₂O, 20 °C)
Vapor pressure<0.1 hPa (50 °C)
Solubility561 g/l soluble
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Packaging Information
Transport Information
Supplemental Information
Specifications
Appearancewhite to almost white, crystalline powder
Assay (alkalimetric, calculated on dried substance)≥ 99.0 %
Identity (IR-spectrum)conforms
pH-value (0.5 mol/l, water)3.5 - 5.0
Melting point147 - 153 °C
UV-Absorption (230 nm; 10 %; 1 cm; water)≤ 0.1
UV-Absorption (260 nm; 10 %, 1 cm; water)≤ 0.06
UV-Absorption (280 nm; 10 %; 1 cm; water)≤ 0.06
UV-Absorption (300 nm; 10 %; 1 cm; water)≤ 0.02
UV-Absorption (400 nm; 10 %; 1 cm; water)≤ 0.01
Residual solvents (ICHQ3C) of class 2 (Methanol)≤ 3000 ppm
Residual solvents (ICHQ3C) of class 2 (Nitromethane)≤ 50 ppm
Residual solvents (ICHQ3C) of class 3 (Ethanol)≤ 5000 ppm
Residual solvents (ICHQ3C) of class 3 (Ethylmethylketon)≤ 5000 ppm
Other residual solvents (ICH Q3C)excluded by manufacturing process
Sulfated ash≤ 0.03
Loss on Drying (105°C)≤ 0.5
Endotoxins< 2.5
Total aerobic microbial count≤ 10²
Total yeast and mould count
≤ 10²
Salmonella spp.
absent in 10 g
E.coli
absent in 1 g
Staphylococcus aureus
absent in 1 g
Pseudomonas aeruginosa
absent in 1 g
Candida albicans
absent in 1 g
Bile tolerante gram negative bacteria
absent in 1 g
DNases (Exo- and endonucleases)
not detected
Proteases
not detected
RNases
not detected
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
Total yeast and mould count
≤ 10²
Salmonella spp.
absent in 10 g
E.coli
absent in 1 g
Staphylococcus aureus
absent in 1 g
Pseudomonas aeruginosa
absent in 1 g
Candida albicans
absent in 1 g
Bile tolerante gram negative bacteria
absent in 1 g
DNases (Exo- and endonucleases)
not detected
Proteases
not detected
RNases
not detected
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).

Documentation

Material Qualification Dossier

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7.0

Quality Management Dossier (Open Access)

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Operational Excellence Dossier

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Tris(hydroxymethyl)aminomethane hydrochloride SDS

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Safety Data Sheet (SDS) 

Tris(hydroxymethyl)aminomethane hydrochloride Certificates of Analysis

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108219

Certificates

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