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676485 VEGFR2 Kinase Inhibitor II - CAS 288144-20-7 - Calbiochem

The VEGFR2 Kinase Inhibitor II, also referenced under CAS 288144-20-7, controls the biological activity of VEGFR2 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (Z)-5-Bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one, Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor II, VEGFR Tyrosine Kinase Inhibitor XIII

Primary Target: VEGF-R2 (KDR/Flk-1)
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      288144-20-7C₁₇H₁₅BrN₂O
      Description
      Overview

      This product has been discontinued.



      A membrane permeant and reversible indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor [IC50 = 70 nM for VEGF-R2 (KDR/Flk-1), 920 nM for PDGF-Rβ, 4.92 µM for p60c-src, and 13.3 µM for FGF-R1]. The inhibition is suggested to be competitive with respect to ATP. Does not inhibit EGF-R kinase activity (IC50 > 100 µM).
      Catalogue Number676485
      Brand Family Calbiochem®
      Synonyms(Z)-5-Bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one, Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor II, VEGFR Tyrosine Kinase Inhibitor XIII
      References
      ReferencesSun, L., et al. 2000. J. Med. Chem. 43, 2655.
      Product Information
      CAS number288144-20-7
      ATP CompetitiveY
      FormBrown solid
      Hill FormulaC₁₇H₁₅BrN₂O
      Chemical formulaC₁₇H₁₅BrN₂O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetVEGF-R2 (KDR/Flk-1)
      Primary Target IC<sub>50</sub>70 nM
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      676485 0

      Documentation

      VEGFR2 Kinase Inhibitor II - CAS 288144-20-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      VEGFR2 Kinase Inhibitor II - CAS 288144-20-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      676485

      References

      Reference overview
      Sun, L., et al. 2000. J. Med. Chem. 43, 2655.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-January-2010 RFH
      Synonyms(Z)-5-Bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one, Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor II, VEGFR Tyrosine Kinase Inhibitor XIII
      DescriptionA cell-permeable and reversible indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor [IC50 = 70 nM for VEGF-R2 (KDR/Flk-1), 920 nM for PDGF-Rβ, 4.92 µM for p60c-src, and 13.3 µM for FGF-R1]. The inhibition is suggested to be competitive with respective to ATP. Also inhibits VEGF-induced (IC50 = 110 nM) and PDGF-induced (IC50 = 2.01 µM) cell proliferation in umbilical vein endothelial cells (HUVEC). Does not exhibit any inhibitory effect on EGF-R kinase activity (IC50 >100 µM).
      FormBrown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number288144-20-7
      Chemical formulaC₁₇H₁₅BrN₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSun, L., et al. 2000. J. Med. Chem. 43, 2655.