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506181 p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 - Calbiochem

p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5, acts as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in dorsal root ganglion & postnatal cerebellar neurons.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: TAT-Pep5, H-YGRKKRRQRRR-CFFRGGFFNHNPRYC-OH, Cyclic

Primary Target: Blocker of MAG- and Nogo-induced inhibition of neurite outgrowth
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506181
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₅₀H₂₂₇N₅₇O₃₂S₂

Pricing & Availability

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506181-500UG
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      		 Plastic ampoule 500 μg
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      Description
      OverviewThe p75NTR inhibitor Pep5 (Cat. No. 506180) is made cell-permeable by fusing it with the N-terminal protein transduction domain sequence (11 amino acids) from HIV protein TAT. Shown to act as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in both DRG (dorsal root ganglion) and postnatal cerebellar neurons. A potential therapeutic agent against inhibition of regeneration in the central nervous system.
      Catalogue Number506181
      Brand Family Calbiochem®
      SynonymsTAT-Pep5, H-YGRKKRRQRRR-CFFRGGFFNHNPRYC-OH, Cyclic
      References
      ReferencesYamashita, T., and Tohyama, M. 2003. Nat. Neurosci. 6, 461.
      Schwarze, S.R., et al. 1999. Science 285, 1569.
      Product Information
      ATP CompetitiveN
      FormLyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₅₀H₂₂₇N₅₇O₃₂S₂
      Chemical formulaC₁₅₀H₂₂₇N₅₇O₃₂S₂
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Applicationp75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5, acts as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in dorsal root ganglion & postnatal cerebellar neurons.
      Biological Information
      Primary TargetBlocker of MAG- and Nogo-induced inhibition of neurite outgrowth
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceH₂N-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys¹²-Phe-Phe-Arg-Gly-Gly-Phe-Phe-Asn-His-Asn-Pro-Arg-Tyr-Cys²⁶-OH
      disulfide bond (12-26)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      506181-500UG 04055977272413

      Documentation

      p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 - Calbiochem Certificates of Analysis

      TitleLot Number
      506181

      References

      Reference overview
      Yamashita, T., and Tohyama, M. 2003. Nat. Neurosci. 6, 461.
      Schwarze, S.R., et al. 1999. Science 285, 1569.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-August-2008 RFH
      SynonymsTAT-Pep5, H-YGRKKRRQRRR-CFFRGGFFNHNPRYC-OH, Cyclic
      DescriptionThe p75NTR inhibitor Pep5 (Cat. No. 506180) fused to the N-terminal, 11-amino acid protein transduction domain sequence from the HIV TAT protein for membrane permeability. Show to inhibit the association of p75NTR with Rho-GDI in vitro. Reported to act as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in dorsal root ganglion (DRG) and postnatal cerebellar neurons at a concentration of 100 nM. Reported to be a potential therapeutic agent for the inhibition of regeneration in the central nervous system.
      FormLyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₅₀H₂₂₇N₅₇O₃₂S₂
      Peptide SequenceH₂N-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys¹²-Phe-Phe-Arg-Gly-Gly-Phe-Phe-Asn-His-Asn-Pro-Arg-Tyr-Cys²⁶-OH
      disulfide bond (12-26)
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesYamashita, T., and Tohyama, M. 2003. Nat. Neurosci. 6, 461.
      Schwarze, S.R., et al. 1999. Science 285, 1569.