telomere
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Hallmarks of Aging | Life Science Research | Merck
The Hallmarks of Aging are rigorously researched phenomena that directly influence aging. Aging is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. The 9 hallmarks include Genomic instability, Telomere attrition, Epigenetic alterations, Loss of proteostasis, Deregulated nutrient sensing, Mitochondrial dysfunction, Cellular senescence, Stem cell exhaustion, Altered intercellular communication. -
DNA Structure, Damage and Repair | Life Science Research | Merck
Studying the mechanisms by which cells control changes in DNA structure and respond to DNA damage will help to elucidate the factors that cause aging, cellular degeneration, cancer, and death. Merck has the antibody solutions you need for your research. -
Nuclear Function | Life Science Research | Merck
A Nuclear function is to be home of an entire genome that can physically fit inside the nucleus and to allow the cell to differentiate, divide, and endure environmental stresses while protecting its valuable genetic information. -
Cellular Senescence | Life Science Research | Merck
Cellular senescence is the point at which our cells stop dividing and growing due to damage or lack of necessary components. As cells age, they lose their ability to actively divide and start to undergo senescence. -
Genomic instability | Life Science Research | Merck
Learn about the environmental factors that can hinder DNA repair. There are many evidence linking genomic and epigenomic changes to disorders involving accelerated aging. Evidence points to general physiological stress and disrupted circadian. It is also possible that decreased DNA repair is also a symptom, not a cause, of aging. To investigate this possibility, researchers will need to examine changes in transcriptional regulators of repair genes, such as ncRNAs, hormones, and other chromatin modulators. -
Validated Cell Types with Scepter™ 2.0 Cell Counter | Life Science Research | Merck
Learn more about our validated dozens of cell types using the Scepter Cell Counter. -
Epigenetics and Nuclear Function | Life Science Research | Merck
Epigenetics describes heritable changes in gene expression caused by non-genetic mechanisms instead of by alterations in DNA sequence. Researchers can count on high quality reagents and expert support for their studies of gene regulation. -
Antibodies for Nuclear Signaling | Life Science Research | Merck
Nuclear signaling regulates gene expression by activating transcriptional activator proteins which can now bind to DNA. -
Small Molecules for Cell Health Applications | Inhibitors & Biochemicals - Life Science Research | Merck
Cell health small molecule inhibitors are essential in the analysis of apoptosis, cell cycle regulation and other areas of focus related to cell viability.