363057
6-O-Methylguanine
97%
Sinónimos:
2-Amino-6-methoxypurine, 6-Methoxyguanine
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C6H7N5O
Número CAS:
Peso molecular:
165.15
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
645384
Assay:
97%
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Permítanos ayudarleInChI
1S/C6H7N5O/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11)
SMILES string
COc1nc(N)nc2[nH]cnc12
InChI key
BXJHWYVXLGLDMZ-UHFFFAOYSA-N
assay
97%
mp
>300 °C (lit.)
Quality Level
Gene Information
human ... CDK2(1017), MGMT(4255)
Categorías relacionadas
General description
6-O-Methylguanine is a purine derivative and its binding affinity has been examined by B. subtilis xpt-pbuX guanine riboswitch (GR) using isothermal titration calorimetry (ITC). 6-O-Methylguanine is formed during the alkylation of a number of purified tRNA preparations, via reaction with the carcinogens, N-methyl-N-nitrosourea .
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Delia Chavarria et al.
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Since methylation at the N-7 and O(6) positions of guanine and the N-3 position of adenine in DNA are the predominant reaction sites, N(7)-methylguanine (N(7)-MeG), O(6)-methylguanine (O(6)-MeG), and N(3)-methyladenine (N(3)-MeA) have been suggested as good biomarkers for assessing exposure to
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