415057
Magnesium stearate
technical grade
Sinónimos:
Stearic acid magnesium salt
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Fórmula lineal:
[CH3(CH2)16CO2]2Mg
Número CAS:
Peso molecular:
591.24
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
209-150-3
Beilstein/REAXYS Number:
3919702
MDL number:
Form:
powder
Servicio técnico
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technical grade
form
powder
composition
palmitate salt, 25% , stearate salt, 65%
mp
200 °C (lit.)
SMILES string
CCCCCCCCCCCCCCCCCC(=O)O[Mg]OC(=O)CCCCCCCCCCCCCCCCC
InChI
1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2
InChI key
HQKMJHAJHXVSDF-UHFFFAOYSA-L
General description
Magnesium stearate (Mg-St) is the magnesium salt of stearic acid. Its anhydrate, dihydrate and trihydrate forms have been prepared. The tabletting of the blends of magnesium stearate and lactose granules has been described. The influence of mixing time on hardness, disintegration time and ejection force on the compressed tablets was examined. Mg-St is widely used lubricant in pharmaceutical industry. It also plays a role in delaying the process of dissolution. Its detection in tablets by laser-induced breakdown spectroscopy has been proposed.
Magnesium stearate, the salt of stearic acid, is widely employed as an inactive component in making pharmaceutical tablets.
Magnesium stearate, the salt of stearic acid, is widely employed as an inactive component in making pharmaceutical tablets.
Application
Magnesium stearate may be used as excipient in the formulations of diclofenac sodium tablets. It may be used for the preparation of tramadol HCl matrix tablets.
Clase de almacenamiento
11 - Combustible Solids
wgk
nwg
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Physical characterization of the polymorphic variations of magnesium stearate and magnesium palmitate hydrate species.
Sharpe SA, et al.
Structural Chemistry, 8(1), 73-84 (1997)
Magnesium stearate, a widely-used food additive, exhibits a lack of in vitro and in vivo genotoxic potential
Hobbs CA, et al.
Toxicology Reports, 4, 554-559 (2017)
Jaleh Varshosaz et al.
AAPS PharmSciTech, 7(1), E24-E24 (2006-04-06)
The objective of this work was to develop matrix sustained-release tablets of highly water-soluble tramadol HCl using natural gums (xanthan [X gum] and guar [G gum]) as cost-effective, nontoxic, easily available, and suitable hydrophilic matrix systems compared with the extensively