739944
Resomer® RG 504, Poly(D,L-lactide-co-glycolide)
lactide:glycolide 50:50, ester terminated, Mw 38,000-54,000
Sinónimos:
PLGA
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Fórmula lineal:
[C3H4O2]x[C2H2O2]y
Número CAS:
MDL number:
UNSPSC Code:
12162002
NACRES:
NA.23
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Permítanos ayudarleSMILES string
O2C(C(=O)OC(C2=O)C)C.O1CC(=O)OCC1=O
InChI
1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2
InChI key
LCSKNASZPVZHEG-UHFFFAOYSA-N
form
amorphous
feed ratio
lactide:glycolide 50:50
mol wt
Mw 38,000-54,000
degradation timeframe
<3 months
viscosity
0.45-0.60 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)
transition temp
Tg 46-50 °C
storage temp.
2-8°C
Quality Level
Categorías relacionadas
Application
Resomer® RG 504, Poly(ᴅ,ʟ-lactide-co-glycolide) can be used to prepare polymeric nanoparticles that are effective carriers for anti-cancer natural substances.
Poly(D, L-lactide-co-glycolide)microspheres can be used to fabricate a hemostatic delivery device forthrombin.
Poly(D, L-lactide-co-glycolide)microspheres can be used to fabricate a hemostatic delivery device forthrombin.
Features and Benefits
Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.
Legal Information
Product of Evonik
RESOMER is a registered trademark of Evonik Rohm GmbH
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Ananthakrishnan Soundaram Jeevarathinam et al.
Angewandte Chemie (International ed. in English) (2019-12-17)
We report a new approach to monitor drug release from nanocarriers via a paclitaxel-methylene blue conjugate (PTX-MB) with redox activity. This construct is in a photoacoustically silent reduced state inside poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PTX-MB@PLGA NPs). During release, PTX-MB is
Vanna Sanna et al.
International journal of nanomedicine, 7, 5501-5516 (2012-10-25)
Resveratrol, like other natural polyphenols, is an extremely photosensitive compound with low chemical stability, which limits the therapeutic application of its beneficial effects. The development of innovative formulation strategies, able to overcome physicochemical and pharmacokinetic limitations of this compound, may
Shu-Chun Chuang et al.
Parasites & vectors, 6, 34-34 (2013-02-13)
Current development efforts of subunit vaccines against Toxoplasma gondii, the etiological agent of toxoplasmosis, have been focused mainly on tachyzoite surface antigen 1 (SAG1). Since microparticles made from poly (lactide-co-glycolide) (PLG) polymers have been developed as safe, potent adjuvants or
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
Teresa Musumeci et al.
International journal of pharmaceutics, 440(2), 135-140 (2012-10-20)
Melatonin, a neurohormone secreted by the pineal gland, is able to modulate intraocular pressure (IOP). The aim of this study was to generate nanoparticle (NPs) sustained release formulations that allow to extend the pre-corneal residence time of melatonin, thus prolonging
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