N3633
β-Naphthoflavone
≥98%
Sinónimos:
beta-Naphthoflavone, 5,6-Benzoflavone, BNF
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Fórmula empírica (notación de Hill):
C19H12O2
Número CAS:
Peso molecular:
272.30
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
227-958-4
Beilstein/REAXYS Number:
18991
MDL number:
Assay:
≥98%
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Permítanos ayudarleNombre del producto
β-Naphthoflavone, ≥98%
InChI key
OUGIDAPQYNCXRA-UHFFFAOYSA-N
InChI
1S/C19H12O2/c20-16-12-18(14-7-2-1-3-8-14)21-17-11-10-13-6-4-5-9-15(13)19(16)17/h1-12H
SMILES string
O=C1C=C(Oc2ccc3ccccc3c12)c4ccccc4
assay
≥98%
color
off-white to yellow
mp
164-166 °C (lit.)
storage temp.
2-8°C
Quality Level
Gene Information
rat ... Gabra2(29706)
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Categorías relacionadas
Application
β-Naphthoflavone has been used:
- as aryl hydrocarbon receptor agonist to elucidate its effect on Cyp1A1 expression in embryos of transgenic cytochrome P450 1A1 (cyp1a) reporter zebrafish
- as AhR agonists, to treat primary normal human epidermal keratinocytes (NHEKs) to study about aryl hydrocarbon receptor (AhR) activation by western blot analysis
- to determine its effect on the expression of dystrophin (Dp)71
- to stimulate the expression of causes recombination (Cre) recombinase and to delete the flanking alleles of locus of crossing (x) over, P1 (loxP) sequences
Biochem/physiol Actions
β-Naphthoflavone (BNF) is an exogenous ligand for aryl hydrocarbon receptor (AhR) in humans. It is an inducer of phase I detoxification enzymes (CYPs) and phase II enzymes (UDP-GTs) and NAD(P)H-dependent quinone oxyreductase-1(NQO1). It also induces cytochrome P450 (Cyp1a). BNF represses the expression of Duchenne muscular dystrophy gene, dystrophin (Dp)71 by altering the binding of the transcription factors.
General description
β-Naphthoflavone is a polyaromatic hydrocarbon.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Journal of Dermatological Science, 73(1), 10-22 (2014)
The polyaromatic hydrocarbon beta-naphthoflavone alters binding of YY1, Sp1, and Sp3 transcription factors to the Dp71 promoter in hepatic cells
Becerril-Esquivel C, et al.
Molecular Medicine Reports, 17(4), 6150-6155 (2018)
Werner Borken et al.
Scientific reports, 6, 39072-39072 (2016-12-16)
Biological N2 fixation (BNF) in the rhizosphere of Podocarpaceae is currently attributed to unspecific diazotrophs with negligible impact on N acquisition. Here, we report specific and high associative BNF in dead cells of root nodules of Lepidothamnus fonkii distributed in
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