P55805
Purine
98%
Sinónimos:
7H-Imidazo(4,5-d)pyrimidine
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C5H4N4
Número CAS:
Peso molecular:
120.11
UNSPSC Code:
12352005
NACRES:
NA.22
PubChem Substance ID:
EC Number:
204-421-2
Beilstein/REAXYS Number:
3200
MDL number:
Assay:
98%
Form:
powder
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Permítanos ayudarleQuality Level
assay
98%
form
powder
mp
214-217 °C (lit.)
SMILES string
c1ncc2nc[nH]c2n1
InChI
1S/C5H4N4/c1-4-5(8-2-6-1)9-3-7-4/h1-3H,(H,6,7,8,9)
InChI key
KDCGOANMDULRCW-UHFFFAOYSA-N
Categorías relacionadas
General description
Purine is a heterocyclic organic compound constituting a pyrimidine ring fused to an imidazole ring.
Application
Purine can undergo direct C-H functionalization in the presence of palladium catalyst to form various biologically important products.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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New developments in direct functionalization of C-H and N-H bonds of purine bases via metal catalyzed cross-coupling reactions.
Abdoli M, et al.
Royal Society of Chemistry Advances, 55(5), 44371-44389 (2015)
Benshang Li et al.
Nature medicine, 21(6), 563-571 (2015-05-12)
Relapse is the leading cause of mortality in children with acute lymphoblastic leukemia (ALL). Among chemotherapeutics, thiopurines are key drugs in ALL combination therapy. Using whole-exome sequencing, we identified relapse-specific mutations in the phosphoribosyl pyrophosphate synthetase 1 gene (PRPS1), which
Silvia Meneghesso et al.
ChemMedChem, 8(3), 415-425 (2013-02-07)
2'-Fluoro-2'-deoxyguanosine has been reported to have potent anti-influenza virus activity in vitro and in vivo. Herein we describe the synthesis and biological evaluation of 6-modified 2'-fluoro-2'-deoxyguanosine analogues and their corresponding phosphoramidate ProTides as potential anti-influenza virus agents. Whereas the parent
Hiroshi Ashihara et al.
Phytochemistry, 69(4), 841-856 (2007-12-11)
Details of the recently elucidated biosynthetic pathways of caffeine and related purine alkaloids are reviewed. The main caffeine biosynthetic pathway is a sequence consisting of xanthosine-->7-methylxanthosine-->7-methylxanthine-->theobromine-->caffeine. Genes encoding N-methyltransferases involved in three of these four reactions have been isolated and
Kansuporn Sriyudthsak et al.
BMC systems biology, 8 Suppl 5, S4-S4 (2015-01-07)
Progress in systems biology offers sophisticated approaches toward a comprehensive understanding of biological systems. Yet, computational analyses are held back due to difficulties in determining suitable model parameter values from experimental data which naturally are subject to biological fluctuations. The
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