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Fórmula empírica (notación de Hill):
C24H40N5O8P
Número CAS:
Peso molecular:
557.58
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
Servicio técnico
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Permítanos ayudarleNombre del producto
NBD Sphingosine-1-Phosphate, Avanti Research™ - A Croda Brand 810207X
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (810207X-100ug), pkg of 1 × 1 mL (810207X-50ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810207X
concentration
0.05 mg/mL (810207X-50ug), 0.1 mg/mL (810207X-100ug)
shipped in
dry ice
storage temp.
−20°C
General description
Sphingosine-1-phosphate is a phosphorylated sphingosine analog and is polar. It is terminally labelled by fluorescent nitrobenzo-2-oxa-1,3-diazole (NBD) group. Sphingosine-1-phosphate is abundantly stored in platelets.
Application
NBD sphingosine-1-phosphate has been used as a substrate in the detection of sphingosine-1-phosphate phosphatases (SPPase) enzymatic activity by in vitro assay.
Biochem/physiol Actions
Sphingosine-1-phosphate (S1P) initiates DNA synthesis. It is also involved in cell division, cell growth and platelet activation. S1P mediates cell movement, differentiation and survival. It specifically stimulates endothelial cells.
Packaging
5 mL Amber Glass Screw Cap Vial (810207X-100ug)
5 mL Amber Glass Screw Cap Vial (810207X-50ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 1 - STOT SE 3
target_organs
Central nervous system
Clase de almacenamiento
3 - Flammable liquids
wgk
WGK 3
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Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes
Ito K, et al.
Biochemical and biophysical research communications, 357(1), 212-217 (2007)
Synthesis of fluorescence-labeled sphingosine and sphingosine 1-phosphate; effective tools for sphingosine and sphingosine 1-phosphate behavior
Hakogi T, et al.
Bioorganic & Medicinal Chemistry Letters, 13(4), 661-664 (2003)
Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function.
Serra M and Saba JD
Advances in Enzyme Regulation, 50(1), 349-362 (2010)