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Merck

D-907

Diazepam solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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Fórmula empírica (notación de Hill):
C16H13ClN2O
Número CAS:
439-14-5
Peso molecular:
284.74
NACRES:
NA.24
PubChem Substance ID:
329798890
UNSPSC Code:
41116107
EC Number:
200-659-6
MDL number:
MFCD00057323

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Nombre del producto

Diazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

InChI key

AAOVKJBEBIDNHE-UHFFFAOYSA-N

InChI

1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3

SMILES string

CN1C(=O)CN=C(c2ccccc2)c3cc(Cl)ccc13

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet
kontrollierte Droge in Deutschland

Quality Level

300

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879)

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

-10 to -25°C

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Application

The Certified Reference Material (CRM) in solution can also be used as follows:
  • Electrochemical determination of diazepam in serum, urine, and tablet formulations by a modified electrode based on fullerene-functionalized carbon nanotubes and ionic liquid (C60-CNTs/IL)
  • Differential voltametric analysis of diazepam in its tablet formulations and human urine samples using a bismuth-modified pre-treated pencil graphite electrode (BiPPGE)
  • Simultaneous quantitative determination of diazepam and flunitrazepam in alcoholic beverage samples by Direct-electron ionization-liquid chromatography-tandem mass spectrometry (EI-LC-MS/MS) method
  • Dispersive nanomaterial-ultrasound assisted-microextraction (DNUM) of diazepam and chlordiazepoxide from urine and plasma samples for their quantification by high-performance liquid chromatography -UV (HPLC-UV) detection
  • Multi-residue analysis of diazepam and its metabolites in human oral fluid samples by their solid-phase extraction followed by LC-MS/MS method-based determination

Features and Benefits

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

General description

This Certified Spiking Solution® is suitable for testing diazepam by HPLC, GC/MS or LC-MS/MS methods in forensic analysis, clinical toxicology, urine drug testing, and cannabis potency or impurity profiling testing applications.

Diazepam is an anxiolytic benzodiazepine drug, commonly used to treat anxiety disorders, muscle spasms, and acute seizures among others.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Clase de almacenamiento

3 - Flammable liquids

wgk

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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A Amiri Pebdani et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1008, 146-155 (2015-12-15)
Benzodiazepines (BDs) are used widely in clinical practice, due to their multiple pharmacological functions. In this study a dispersive nanomaterial-ultrasound assisted- microextraction (DNUM) method followed by high performance liquid chromatography (HPLC) was used for the preconcentration and determination of chlordiazepoxide
Voltammetric determination of diazepam using a bismuth modified pencil graphite electrode
Dehghanzade M and Alipour E
Analytical Methods : Advancing Methods and Applications, 8, 1995-2004 (2016)
Electrochemical determination of diazepam in real samples based on fullerene-functionalized carbon nanotubes/ionic liquid nanocomposite
Rahimi-Nasrabadi M, et al.
Sensors and Actuators B, Chemical, 240, 125-131 (2017)
Berend Malchow et al.
Journal of neural transmission (Vienna, Austria : 1996), 122(7), 1019-1033 (2014-10-14)
Hippocampus volumes have been shown to be decreased in patients with major depression, but volume measurements are inconsistent in patients with bipolar disorder. Both disorders are associated with deficits in hippocampus-mediated cognitive functions. However, the underlying pathophysiology is widely unknown.
Haim Bassan et al.
Epilepsia, 54(6), 1092-1098 (2013-04-05)
Prolonged febrile seizures (PFS) lasting ≥15 min have been associated with increased risk for epilepsy in later life. Initial treatment, mostly prehospital, aims to prevent its evolution to febrile status epilepticus (FSE) and reduce adverse outcome. Paucity of information is
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