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ZM 241385

A highly potent, selective, non-xanthine adenosine A2A receptor antagonist (Ki = 800 pM for human adenosine A2AR stably expressed in HEK-293 cells).

Sinónimos:

Adenosine A2A Receptor Antagonist I, ZM 241385

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Fórmula empírica (notación de Hill):
C16H15N7O2
Número CAS:
139180-30-6
Peso molecular:
337.34
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00908394
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
OK to freeze, protect from light
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Nombre del producto

Adenosine A2A Receptor Antagonist I, ZM 241385, A highly potent, selective, non-xanthine adenosine A2A receptor antagonist (Ki = 800 pM for human adenosine A2AR stably expressed in HEK-293 cells).

Quality Level

100

assay

≥98% (HPLC)

form

powder

potency

800 pM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 15 mg/mL

application(s)

air monitoring

compatibility

for use with Viable Air Samplers (1.09191), for use with Viable Air Samplers (1.09194), for use with Viable Air Samplers (1.17103), for use with Viable Air Samplers (1.17274), for use with Viable Air Samplers (1.17275)

shipped in

ambient

storage temp.

2-8°C

SMILES string

[n]21nc(nc2nc(nc1N)NCCc4ccc(cc4)O)c3[o]ccc3

InChI

1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22)

InChI key

PWTBZOIUWZOPFT-UHFFFAOYSA-N

General description

A highly potent, selective, and orally bioavailable non-xanthine adenosine A2A receptor antagonist (Ki = 800 pM for human adenosine A2AR stably expressed in HEK-293 cells). Does not exhibit any significant antagonistic activity in A1, A2B (Ki = 255 nM and 50 nM, respectively in human adenosine receptors stably expressed in CHO cells) or in A3R (Ki >10 µM in human A3R stably expressed in HEK-293 cells). Shown to have a protective effect against beta-amyloid peptide toxicity.
A highly potent, selective, non-xanthine adenosine A2A receptor antagonist (Ki = 800 pM for human adenosine A2AR stably expressed in HEK-293 cells).

Biochem/physiol Actions

Primary Target
A2A
Reversible: yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Poucher, S. M., et al. 1995. Brit. J. Pharmacol. 115, 1096.
Ongini, E. et al. 1999. Naunyn Schmiedebergs Arch Pharmacol. 359, 7.

Keddie, J. et al. 1996, Eur Journ Pharm. 301, 107.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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