Lck Protein, activated, 10 µg

origen biológico

human

Nivel de calidad

100

recombinante

expressed in baculovirus infected Sf21 cells

Línea del producto

Upstate^®

actividad específica

(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)

mol peso

M_w 59 kDa

purificado por

(Ni²⁺/NTA-agarose)

reactividad de especies

human

fabricante / nombre comercial

Upstate^®

técnicas

activity assay: suitable (kinase)

nº de acceso

 (FUNCTION: SwissProt: P06239 # Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated LCK to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (ITAMs) in the cytoplasmic tails of the TCRgamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. In addition, contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, and upon engagement of the CD2 molecule, LCK undergoes hyp)
NM_005356.3

Nº de acceso NCBI

NM_005356.3

Nº de acceso UniProt

P06239

enfermedades relevantes

obesity; metabolic disorders