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211280

Capsazepine

Name: Capsazepine
Brand: MM

≥97% (HPLC), Capsaicin and resiniferatoxin antagonist, solid

Sinónimos:

Capsazepine, N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide

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Fórmula empírica (notación de Hill):

C₁₉H₂₁ClN₂O₂S

Número CAS:

138977-28-3

Peso molecular:

376.90

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00153778

Assay:

≥97% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze

Servicio técnico

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Propiedades

Nombre del producto

Capsazepine, A competitive antagonist of Capsaicin and resiniferatoxin. Capsazepine (1 µM) blocks capsaicin (60 nM) stimulated firing of C-fibers.

Quality Level

100

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

off-white

solubility

DMSO: soluble, methanol: soluble

shipped in

ambient

storage temp.

10-30°C

SMILES string

S=C(N2CCCc3c(cc(c(c3)O)O)C2)NCCc1ccc(cc1)Cl

InChI

1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)

InChI key

DRCMAZOSEIMCHM-UHFFFAOYSA-N

Descripción

General description

A competitive antagonist of Capsaicin (Cat. No. 211274) and resiniferatoxin. Capsazepine (1 µM) blocks capsaicin (60 nM) stimulated firing of C-fibers.

A competitive antagonist of the sensory neuron excitants capsaicin (Cat. No. 211274) and resiniferatoxin (Cat. No. 553975). Capsazepine (1 µM) blocks capsaicin (60 nM) stimulated firing of C-fibers.

Biochem/physiol Actions

Cell permeable: no

Primary Target
A competitive antagonist of Capsaicin and resiniferatoxin

Product does not compete with ATP.

Reversible: no

Preparation Note

Unstable in solution; reconstitute just prior to use.

Other Notes

Fox, A.J., et al. 1995. Neuroscience 67, 741.
Ellis, J.L., and Undem, B.J. 1994. J. Pharmacol. Exp. Ther. 268, 85.
Walpole, C.S.J., et al. 1994. J. Med. Chem.37, 1942.
Szallasi, A., et al. 1993. J. Pharmacol. Exp. Therap.267, 728.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c