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234115

Colchicine

Name: Colchicine
Brand: MM

From Colchicum autumnale, is an inhibitor of mitosis that disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in PC12 and cerebellar granule cells

別名:

Colchicine, Colchicum autumnale

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この商品について

実験式（ヒル表記法）:

C₂₂H₂₅NO₆

CAS番号:

64-86-8

分子量:

399.44

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00078484

Assay:

≥94% (HPLC)

Form:

powder

Storage condition:

OK to freeze, protect from light

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特性

製品名

Colchicine, Colchicum autumnale, Colchicine, Colchicum autumnale, CAS 64-86-8, is an inhibitor of mitosis that disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in PC12 and cerebellar granule cells.

Quality Segment

100

description

Merck USA index - 14, 2471

assay

≥94% (HPLC)

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow to off-white

solubility

ethanol: 10 mg/mL, water: soluble

shipped in

ambient

storage temp.

10-30°C

SMILES string

N([C@H]1CCc2c(c(c(c(c2)OC)OC)OC)c3c1c[c](c(cc3)OC)=O)C(=O)C

InChI

1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1

InChI key

IAKHMKGGTNLKSZ-INIZCTEOSA-N

詳細

General description

Inhibitor of mitosis that is useful in cell division studies. Disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in PC12 cells and in cerebellar granule cells.

Major alkaloid of Colchicum autumnale. Inhibitor of mitosis used in cell division studies. Disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in pheochromocytoma (PC12) cells and in cerebellar granule cells.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Inhibitor of mitosis

Product does not compete with ATP.

Reversible: no

Other Notes

Bonfoco, E., et al. 1995. Exp. Cell Res.218, 189.
Lindenboim, L., et al. 1995. J. Neurochem.64, 1054.
Leung, M.F., and Sartorelli, A.C. 1992. Leuk. Res.16, 929.
Santell, L. 1992. Exp. Cell Res. 201, 358.
Salmon, E.D., et al. 1984. J. Cell Biol.99, 1066.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H300,H340

pcodes

P202 - P264 - P280 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 2 Oral - Muta. 1B

保管分類

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c