Anti-v-Src Antibody, clone 327

v-Src is the product of the Rous sarcoma virus (RSV) oncogene, and functions as a non-receptor tyrosine kinase belonging to the family of Src proteins. Srcs are typically activated by dimerized cell surface receptors such as integrins, receptor tyrosine kinases, and cytokine receptors. Activated Src kinases phosphorylate the cytoplasmic domains of these receptors enabling interaction between these receptors and their downstream effector molecules. Src proteins are involved in many cellular processs such as apoptosis, immunity, gene expression, cell adhesion, cell migration, and cell transformation. Previous studies have reported that v-Src plays an important role in tumorigenesis.

Recombinant protein corresponding to purified pp60src from bacterial recombinants which direct the synthesis of v-Src.

Anti-v-Src Antibody, clone 327 detects level of v-Src & has been published & validated for use in Western Blotting.

Research Category
Signaling

Research Sub Category
Immunological Signaling

Evaluated by Western Blot in NIH/3T3 cell lysate.

Western Blot Analysis: 0.1 µg/mL of this antibody detected v-Src in 10 µg of NIH/3T3 cell lysate.

~60 kDa observed

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
NIH/3T3 cell lysate

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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