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Merck

31736

Sulfadoxina

VETRANAL®, analytical standard

Sinónimos:

4-amino-N-(5,6-dimetoxi-4-pirimidinil)benzenosulfamida, Sulfadoxina

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Fórmula empírica (notación de Hill):
C12H14N4O4S
Número CAS:
2447-57-6
Peso molecular:
310.33
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329753909
EC Number:
219-504-9
Beilstein/REAXYS Number:
625453
MDL number:
MFCD00792890

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InChI key

PJSFRIWCGOHTNF-UHFFFAOYSA-N

InChI

1S/C12H14N4O4S/c1-19-10-11(14-7-15-12(10)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)

SMILES string

COc1ncnc(NS(=O)(=O)c2ccc(N)cc2)c1OC

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

storage temp.

2-8°C

Quality Level

100

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General description

Chemical structure: sulfonamide
Sulfadoxin belongs to the long acting group of sulfonamides, which acts by inhibiting dihydropteroate synthase in intracellular sporozoa such as Eimeria and Toxoplasma and Plasmodium.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Sulfadoxin may be used as a reference standard for the determination of the analyte in plasma samples using packed-column supercritical fluid chromatography (SFC).

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H317,H411

Hazard Classifications

Aquatic Chronic 2 - Skin Sens. 1

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
BCCK1960
BCCC5858
BCBV7742
BCBS4285V

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Determination of sulfadoxine in human blood plasma using packed-column supercritical fluid chromatography.
Bhoir IS, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 757(1) (2001)
Encyclopedic Reference of Parasitology, 2(2) (2001)
Arti Basra et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 56(6), e68-e75 (2012-11-24)
Urogenital schistosomiasis is a major public health problem in sub-Saharan Africa, and routine programs for screening and treatment of pregnant women are not established. Mefloquine-currently evaluated as a potential alternative to sulfadoxine-pyrimethamine as intermittent preventive treatment against malaria in pregnancy
Alexia Daoust et al.
NeuroImage, 96, 133-142 (2014-04-08)
The MAP6 (microtubule-associated protein 6) KO mouse is a microtubule-deficient model of schizophrenia that exhibits severe behavioral disorders that are associated with synaptic plasticity anomalies. These defects are alleviated not only by neuroleptics, which are the gold standard molecules for
Anna Maria van Eijk et al.
The Lancet. Infectious diseases, 13(12), 1029-1042 (2013-09-24)
Pregnant women in malaria-endemic countries in sub-Saharan Africa are especially vulnerable to malaria. Recommended prevention strategies include intermittent preventive treatment with two doses of sulfadoxine-pyrimethamine and the use of insecticide-treated nets. However, progress with implementation has been slow and the
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