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Merck

940356

GPhos Pd G3 ChemBeads

greener alternative

solid

Sinónimos:

Methanesulfonato[Dicyclohexyl[3-(1,1-dimethylethoxy)-6-methoxy-2′,6′-bis(1-methylethyl)[1,1′-biphenyl]-2-yl]phosphine](2′-amino-1,1′-biphenyl-2-yl)palladium(II) ChemBeads

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Acerca de este artículo

Fórmula empírica (notación de Hill):
C48H66NO5PPdS
Número CAS:
2489525-82-6
Peso molecular:
906.50
MDL number:
MFCD34549924
UNSPSC Code:
12352100
NACRES:
NA.21

Documentos clave

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Nombre del producto

GPhos Pd G3 ChemBeads,

SMILES string

CC(C(C=CC=C1C(C)C)=C1C(C(OC)=CC=C2OC(C)(C)C)=C2P(C3CCCCC3)C4CCCCC4)C.[MsO][Pd]5C6=CC=CC=C6C7=CC=CC=C7N5

InChI

InChI=1S/C35H53O2P.C12H10N.CH4O3S.Pd/c1-24(2)28-20-15-21-29(25(3)4)32(28)33-30(36-8)22-23-31(37-35(5,6)7)34(33)38(26-16-11-9-12-17-26)27-18-13-10-14-19-27;13-12-9-5-4-8-11(12)10-6-2-1-3-7-10;1-5(2,3)4;/h15,20-27H,9-14,16-19H2,1-8H3;1-6,8-9H,13H2;1H3,(H,2,3,4);/q;;;+1/p-1

InChI key

PLMOFCQYSAAMKA-UHFFFAOYSA-M

Quality Level

100

greener alternative product characteristics

Waste Prevention
Catalysis
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

greener alternative category

Aligned

product line

ChemBeads

form

solid

composition

, 4-6 wt. % (loading)

reaction suitability

reagent type: catalyst

Categorías relacionadas

General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of the 12 Principles of Greener Chemistry. ChemBeads are advanced solid-coated beads for high-throughput experimentation in various chemical applications. They enable precise dispensing of solid reagents, allowing researchers to conduct reactions with minimal material use, thus supporting waste prevention and catalysis principles while ensuring accuracy and reproducibility. This technology enhances efficiency and streamlines experimental processes in chemistry. Click here for more information.
The ChemBeads product of the GPhos ligand combined with the Buchwald third Generation Palladacycle. The GPhos motif gives superb activity while having greater stability relative to other superbulky Buchwald ligands. Loaded at 5% wt. on glass beads for use in high-throughput expermentation (HTE). GPhos Pd G3 has been used in: - The production of chiral N-arylamines via a telescoped transaminase-Buchwald-Hartwig Amination cascade.

Application

ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical. For general uses, product is also available in powdered form (920460 )

Features and Benefits

ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

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Certificados de análisis (COA)

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Christian M Heckmann et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 27(67), 16616-16620 (2021-09-30)
The combination of biocatalysis and chemocatalysis can be more powerful than either technique alone. However, combining the two is challenging due to typically very different reaction conditions. Herein, chiral N-aryl amines, key features of many active pharmaceutical ingredients, are accessed
Scott D McCann et al.
Journal of the American Chemical Society, 142(35), 15027-15037 (2020-08-14)
We have developed a new dialkylbiaryl monophosphine ligand, GPhos, that supports a palladium catalyst capable of promoting carbon-nitrogen cross-coupling reactions between a variety of primary amines and aryl halides; in many cases, these reactions can be carried out at room
Bryan T Ingoglia et al.
Tetrahedron, 75(32), 4199-4211 (2020-01-04)
Over the past three decades, Pd-catalyzed cross-coupling reactions have become a mainstay of organic synthesis. In particular, catalysts derived from biaryl monophosphines have shown wide utility in forming C-N bonds under mild reaction conditions. This work summarizes a variety of
Noah P Tu et al.
Angewandte Chemie (International ed. in English), 58(24), 7987-7991 (2019-03-21)
Technologies that enable rapid screening of diverse reaction conditions are of critical importance to methodology development and reaction optimization, especially when molecules of high complexity and scarcity are involved. The lack of a general solid dispensing method for chemical reagents
Ana L Aguirre et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 27(51), 12981-12986 (2021-07-08)
High-throughput experimentation (HTE) methods are central to modern medicinal chemistry. While many HTE approaches to C-N and Csp2 -Csp2 bonds are available, options for Csp2 -Csp3 bonds are limited. We report here how the adaptation of nickel-catalyzed cross-electrophile coupling of

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