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Merck

B1045000

Betamethasone sodium phosphate

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

Betamethasone 21-phosphate disodium

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Fórmula empírica (notación de Hill):
C22H28FNa2O8P
Número CAS:
151-73-5
Peso molecular:
516.40
NACRES:
NA.24
PubChem Substance ID:
329773157
UNSPSC Code:
41116107
MDL number:
MFCD00200361

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InChI

1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15-,16-,17-,19-,20-,21-,22-;;/m0../s1

SMILES string

[Na+].[Na+].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@H](C)[C@]4(O)C(=O)COP([O-])([O-])=O

InChI key

PLCQGRYPOISRTQ-LWCNAHDDSA-L

grade

pharmaceutical primary standard

API family

betamethasone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... NR3C1(2908)

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General description

Betamethasone is a corticosteroid with anti-inflammatory and immunosuppressive abilities, used especially where water retention is undesirable. It is applied as a topical cream, ointment, lotion or gel to treat itching (e.g. from eczema). Corticosteroid used to stimulate fetal lung maturation and to decrease the incidence and mortality from intracranial hemorrhage in premature infants
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Betamethasone sodium phosphate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B - STOT RE 2

target_organs

Liver,Kidney,Endocrine system

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Hiroshi Toshida et al.
Eye & contact lens, 35(3), 156-158 (2009-05-08)
To report a case of microcysts in the cornea of a female who wore silicone hydrogel contact lenses (CLs) including observation by an in vivo confocal laser microscope. A 31-year-old woman who wore Acuvue Oasys CLs was referred to our
George Habib et al.
Clinical rheumatology, 28(1), 85-87 (2008-10-15)
To evaluate the effect of intra-articular steroid injection (IASI) of betamethasone acetate/betamethasone sodium phosphate (Celestone Chronodose) at the knee joint on blood glucose and fructosamine levels in controlled diabetic patients with osteoarthritis of the knee. Controlled diabetic patients (HgA1C <
Ibrahim Coban et al.
Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons, 15(1), 22-27 (2009-02-17)
To determine the effects of human amniotic fluid and membrane in the treatment of Achilles tendon ruptures, 72 tendons of 36 Wistar rats were injected with betamethasone sodium phosphate. By the end of fourth week, both tendons were tenotomized and
Jun Lu et al.
Journal of chromatography. A, 1217(44), 6932-6941 (2010-09-22)
Betamethasone Sodium Phosphate and Betamethasone Acetate are the two corticosteroids active pharmaceutical ingredients (APIs) that are present in the injectable formulation, Celestone Chronodose(®) Injection. It is extremely challenging to develop a Quality Control friendly HPLC method to separate all the
Tsutomu Sakai et al.
Investigative ophthalmology & visual science, 52(3), 1516-1521 (2010-12-24)
The therapeutic effects of betamethasone phosphate (BP) encapsulated in biocompatible and biodegradable blended nanoparticles of poly(lactic acid) (PLA) homopolymers and PEG-block-PLA copolymers (stealth nanosteroids) were examined in an experimental autoimmune uveoretinitis (EAU) model in Lewis rats. EAU was induced by
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