SMB01318
3-Hydroxydesloratadine
Sinónimos:
3-Hydroxy Desloratadine, Desloratadine 3-Hydroxy Impurity
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Fórmula empírica (notación de Hill):
C19H19ClN2O
Número CAS:
Peso molecular:
326.82
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥90%
Form:
solid
Servicio técnico
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Permítanos ayudarledescription
Modulation and Signaling
Quality Level
assay
≥90%
form
solid
technique(s)
HPLC: suitable
color
pale yellow to off-white
storage temp.
−20°C
SMILES string
Clc1cc2c(cc1)C(=C4CCNCC4)c3ncc(cc3CC2)O
InChI
1S/C19H19ClN2O/c20-15-3-4-17-13(9-15)1-2-14-10-16(23)11-22-19(14)18(17)12-5-7-21-8-6-12/h3-4,9-11,21,23H,1-2,5-8H2
InChI key
NDFMTPISBHBIKE-UHFFFAOYSA-N
General description
3-hydroxy Desloratadine is a major metabolite of desloratadine and loratadine, which are non-sedating tricyclic antagonists of the histamine H1 receptor and antihistamine drugs used to manage allergic rhinitis and chronic idiopathic urticaria.
Application
3-Hydroxy Desloratadine finds application in metabolomics and drug discovery research
Biochem/physiol Actions
3-hydroxydesloratadine formation involves the oxidation of desloratadine by cytochrome P450 (CYP2C8) and subsequent glucuronidation by UDP-glucuronosyltransferase UGT2B10 in cryopreserved human hepatocytes. This pathway leads to the production of 3-hydroxydesloratadine, a major active human metabolite.
Features and Benefits
- High quality compound suitable for multiple research applications
- Compatible with a wide variety of chromatographic and spectrometry techniques
Other Notes
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This product is intended for research purposes only, and it is not meant for human consumption.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Matti K Itkonen et al.
Drug metabolism and disposition: the biological fate of chemicals, 47(4), 377-385 (2019-01-12)
A recent in vitro study suggested that CYP2C8 is essential in the metabolism of desloratadine, an H1 receptor antagonist. If the proposed biotransformation mechanism takes place in vivo in humans, desloratadine could serve as a selective CYP2C8 probe substrate in
Silvi A Chacko et al.
Xenobiotica; the fate of foreign compounds in biological systems, 50(6), 621-629 (2019-10-01)
Accurate prediction of in vivo metabolic pathways in humans can be challenging because in vitro liver matrices may fail to produce certain in vivo metabolites.Rat and human spheroids, generated from cryopreserved hepatocytes in media that contained minimal amount of serum
Faraz Kazmi et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(4), 523-533 (2015-01-18)
Desloratadine (Clarinex), the major active metabolite of loratadine (Claritin), is a nonsedating long-lasting antihistamine that is widely used for the treatment of allergic rhinitis and chronic idiopathic urticaria. For over 20 years, it has remained a mystery as to which