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Merck

53747

Hyaluronic acid sodium salt from Streptococcus equi

bacterial glycosaminoglycan polysaccharide

Sinónimos:

Poly(β-glucuronic acid-[1→3]-β-N-acetylglucosamine-[1→4]), alternating

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About This Item

Número CAS:
9067-32-7
MDL number:
MFCD00875848
UNSPSC Code:
51202002
PubChem Substance ID:
24878223
NACRES:
NA.25

Nombre del producto

Hyaluronic acid sodium salt from Streptococcus equi, bacterial glycosaminoglycan polysaccharide

SMILES string

[Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2C([O-])=O

InChI

1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1

InChI key

YWIVKILSMZOHHF-QJZPQSOGSA-N

biological source

(Streptococcus equi)

form

powder or crystals

mol wt

~1.5-1.8 x 10E6 Da

impurities

≤1% protein

color

white

solubility

H2O: 5 mg/mL, clear, colorless

storage temp.

−20°C

Quality Level

200

Categorías relacionadas

Application

Hyaluronic acid sodium salt from Streptococcus equi has been used:
  • with methacrylic anhydride for synthesizing cross-linkable methacrylated HA hydrogel (Coll-MeHA)
  • in phosphate buffer saline (PBS) to replace the PBS bath to vary the lubricant composition
  • in the preparation of lubricant to study its effects on the boundary lubrication of human osteoarthritis (OA) cartilage

Biochem/physiol Actions

Hyaluronic acid (HA), an important component of synovial fluid and articular cartilage serves as the boundary lubricant. It exhibits several physicochemical properties including biodegradability, biocompatibility, nontoxicity, and nonimmunogenicity. HA is considered a great tool for biomedical uses like drug delivery, tissue engineering, plastic surgery, ocular surgery, and osteoarthritis surgery. It participates in cushioning and lubricating the body. This powerful antioxidant can bond water to tissue.

General description

Hyaluronic acid (HA), a vital component of the extracellular matrix in the central nervous system, is the versatile macromolecule found in the connective tissues of all vertebrates. This supramolecular glycosaminoglycan is a polyanionic natural polymer occurring as a linear polysaccharide. It is made up of glucuronic acid and N-acetylglucosamine repeats through a β-1,4 linkage. HA is seen abundantly in the eyes, joints, and heart valves.

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000431155
0000431155
0000464558
0000464558
BCCN0155

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the molecular weight of Product 53747, Hyaluronic acid sodium salt from Streptococcus equi?

    According to our supplier, the molecular weight of Product 53747 is approximately 1.5  to 1.8 X 10E6 Dalton.

  4. How should I store Product 53747, Hyaluronic acid sodium salt from Streptococcus equi?

    This product should be stored at - 20 °C.

  5. Can Product 53747, Hyaluronic acid, be sterilized?

    Yes, according to references you can autoclave Hyaluronic acid sodium salt from Streptococcus equi.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Jae-Yong Park et al.
PloS one, 9(11), e112684-e112684 (2014-11-27)
Synovial fluid plays an important role in lubricating synovial joints. Its main constituents are hyaluronic acid (HA) and γ-globulin, acting as boundary lubricants for articular cartilage. The aim of the study was to demonstrate the concentration-dependent effect of HA and
Telma E Santos et al.
Cell reports, 32(3), 107907-107907 (2020-07-23)
During development of the central nervous system (CNS), neurons polarize and rapidly extend their axons to assemble neuronal circuits. The growth cone leads the axon to its target and drives axon growth. Here, we explored the mechanisms underlying axon growth
Wei-Yao Chen et al.
Frontiers in endocrinology, 12, 572690-572690 (2021-03-30)
The global obesity population is increasing year-by-year, and the related cost is sharply increasing annually. There are several methods available to combat obesity; however, there is a lack of a single tool that is both safe and efficacious. The use
H C Lin et al.
European cells & materials, 40, 133-145 (2020-09-21)
Vascularisation efficiency plays an essential role in the success of bulk transplantation, while biocompatibility and safety are major concerns in clinical applications. Fibrin-based hydrogels have been exploited as scaffolds for their advantages in biocompatibility, degradability and mass transportation in various
Tao Jin et al.
Biomaterials, 113, 176-190 (2016-11-07)
Extracellular matrix (ECM) is widely used as an inductive biological scaffold to repair soft tissue after injury by promoting functional site-appropriate remodeling of the implanted material. However, there is a lack of non-invasive analysis methods to monitor the remodeling characteristics
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