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Merck

73144

Resorufin

95%

Sinónimos:

7-Hydroxy-3H-phenoxazin-3-one, NSC 12097

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About This Item

Fórmula empírica (notación de Hill):
C12H7NO3
Número CAS:
635-78-9
Peso molecular:
213.19
UNSPSC Code:
12171500
NACRES:
NA.32
PubChem Substance ID:
329764655
EC Number:
211-241-8
Beilstein/REAXYS Number:
174850
MDL number:
MFCD00128991

Nombre del producto

Resorufin, 95%

InChI

1S/C12H7NO3/c14-7-1-3-9-11(5-7)16-12-6-8(15)2-4-10(12)13-9/h1-6,14H

InChI key

HSSLDCABUXLXKM-UHFFFAOYSA-N

SMILES string

O=C(C=C1)C=C2C1=NC3=CC=C(O)C=C3O2

assay

≥95.0% (HPLC)
95%

form

solid

mp

>300 °C (lit.)

storage temp.

−20°C

Quality Level

100

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General description

Red fluorophore standard. Widely used in enzyme assay systems. Absorption and fluorescence of resorufin are pH dependent. Below the pKa (~6.0), Abs. shifts to ~ 480 nm and both E and fluorescence quantum yield are markedly lower. Resorufin is unstable in the presence of thiols such as dithiothreitol (DTT) and 2-mercaptoethanol.
Resorufin has high extinction coefficient and good chemical and photostability. These properties of resorufin make it perfect for its usage in inverse fluorescence assay to detect H2O2 by measuring the disappearance of its fluorescence upon horseradish peroxidase-mediated oxidation to a nonfluorescent derivative.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
BCCN8252
BCCL9014
BCCK6305
BCCK1338
BCCK1337

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A stable nonfluorescent derivative of resorufin for the fluorometric determination of trace hydrogen peroxide: applications in detecting the activity of phagocyte NADPH oxidase and other oxidases.
Zhou M, et al.
Analytical Biochemistry, 253(2), 162-168 (1997)
Matteo Miceli et al.
Molecules (Basel, Switzerland), 24(12) (2019-06-19)
Monoacylglycerol lipase (MAGL) is a serine hydrolase that has a key regulatory role in controlling the levels of 2-arachidonoylglycerol (2-AG), the main signaling molecule in the endocannabinoid system. Identification of selective modulators of MAGL enables both to provide new tools
Julian G Jude et al.
Oncogene, 34(10), 1253-1262 (2014-04-01)
Given the importance of deregulated phosphoinositide (PI) signaling in leukemic hematopoiesis, genes coding for proteins that regulate PI metabolism may have significant and as yet unappreciated roles in leukemia. We performed a targeted knockdown (KD) screen of PI modulator genes
Ahmed A El-Sherbeni et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1498-1507 (2014-06-28)
Cytochrome P450 (P450) enzymes mediate arachidonic acid (AA) oxidation to several biologically active metabolites. Our aims in this study were to characterize AA metabolism by different recombinant rat P450 enzymes and to identify new targets for modulating P450-AA metabolism in
Charlotte Jendresen et al.
Scientific reports, 9(1), 4600-4600 (2019-03-16)
Amyloid-β (Aβ) is the main constituent of amyloid deposits in Alzheimer's disease (AD). The neuropathology is associated with neuroinflammation. Here, we investigated effects of systemic lipopolysaccharide (LPS)-treatment on neuroinflammation and Aβ deposition in AβPP-mice and double-transgenic mice with brain expression
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