A4034

(+)-Sodium L-ascorbate

Name: (+)-Sodium <SC>L</SC>-ascorbate
Brand: SIGMA

powder, BioReagent, suitable for cell culture

Sinónimos:

L(+)-Ascorbic acid sodium salt, Vitamin C sodium salt

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About This Item

Fórmula empírica (notación de Hill):

C₆H₇NaO₆

Número CAS:

134-03-2

Peso molecular:

198.11

NACRES:

NA.75

PubChem Substance ID:

24890738

eCl@ss:

34058010

UNSPSC Code:

12352205

EC Number:

205-126-1

MDL number:

MFCD00082340

Beilstein/REAXYS Number:

3767246

Nombre del producto

(+)-Sodium L-ascorbate, powder, BioReagent, suitable for cell culture

InChI key

PPASLZSBLFJQEF-RXSVEWSESA-M

InChI

1S/C6H8O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,7-10H,1H2;/q;+1/p-1/t2-,5+;/m0./s1

SMILES string

[Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-]

biological source

synthetic (organic)

product line

BioReagent

assay

≥98%

form

powder

mol wt

M_w 198.11 g/mol

technique(s)

cell culture | mammalian: suitable
cell culture | plant: suitable

color

white to off-white

mp

220 °C (dec.) (lit.)

solubility

H₂O: 50 mg/mL

Quality Level

200

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Categorías relacionadas

Biochemicals

Cell Culture & Analysis

Cell Culture Media & Buffers

Cell Culture Supplements & Reagents

Chemistry & Biochemicals

Application

(+)-Sodium L-ascorbate has been used:

to produce H₂O₂ in cell culture media
as a reducing agent for a cell-permeable artificial electron donor, N,N,N′,N′-tetramethyl-p-phenylenediamine (TMPD)
to study its effect on production of collagen and elastic fibers in fibroblasts cultures derived from normal human skin and dermal fat

Used for preparation of plant extracts; reductant for the isolation of chloroplasts.

Biochem/physiol Actions

Antioxidant

General description

(+)-Sodium L-ascorbate (SA) is a potential antioxidant and is a derivative of vitamin C (L-ascorbic acid). It is widely used as a food additive. In addition, SA enhances growth retardation activity of bleomycin sulfate, R020-1724 (an inhibitor of cyclic nucleotide phosphodiesterase), prostaglandin E1 and sodium butyrate agents on neuroblastoma cells in culture. Elevated levels of SA induces two-stage urinary bladder carcinogenesis in rats. sodium L-ascorbate in combination with collagenogenesis inhibitors is used to treat dermal scars and keloids.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

ppe

Eyeshields, Gloves, type N95 (US)

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Sodium ascorbate potentiates the growth inhibitory effect of certain agents on neuroblastoma cells in culture

Prasad KN, et al.

Proceedings of the National Academy of Sciences of the USA, 76(2), 829-832 (1979)

Promoting effects of sodium L-ascorbate on two-stage urinary bladder carcinogenesis in rats

Fukushima S, et al.

Cancer Research, 43(9), 4454-4457 (1983)

Artefacts in cell culture: pyruvate as a scavenger of hydrogen peroxide generated by ascorbate or epigallocatechin gallate in cell culture media

Long LH and Halliwell B

Biochemical and Biophysical Research Communications, 388(4), 700-704 (2009)

The putative Drp1 inhibitor mdivi-1 is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species

Bordt EA, et al.

Developmental Cell, 40(6), 583-594 (2017)

Artefacts in cell culture: alpha-Ketoglutarate can scavenge hydrogen peroxide generated by ascorbate and epigallocatechin gallate in cell culture media