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Merck

A7699

Adenosina 5′-trifosfato disodium salt hydrate

BioXtra, ≥99% (HPLC), from microbial

Sinónimos:

ATP disodium salt

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About This Item

Fórmula empírica (notación de Hill):
C10H14N5Na2O13P3 · xH2O
Número CAS:
34369-07-8
Peso molecular:
551.14 (anhydrous basis)
PubChem Substance ID:
24891270
eCl@ss:
32160414
UNSPSC Code:
41106305
NACRES:
NA.51
EC Number:
213-579-1
MDL number:
MFCD00150755

Nombre del producto

Adenosina 5′-trifosfato disodium salt hydrate, BioXtra, ≥99% (HPLC), from microbial

InChI key

NTBQNWBHIXNPRU-MSQVLRTGSA-L

InChI

1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1

SMILES string

O.[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O

biological source

microbial

product line

BioXtra

assay

≥99% (HPLC)

form

powder

Quality Level

300

mol wt

551.14 g/mol

impurities

≤0.1% inorganic P
≤3% solvent content

color

white

pKa 

(1) 4.0, (2) 6.5

solubility

H2O: 50 mg/mL, clear, colorless

anion traces

chloride (Cl-): ≤0.05%

cation traces

Al: ≤0.005%
Ca: ≤0.01%
Cu: ≤0.001%
Fe: ≤0.05%
K: ≤0.01%
Mg: ≤0.005%
NH4+: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.0005%

λmax

259 nm

fluorescence

λem 15.4 in 0.1 M phosphate pH 7.0

storage temp.

−20°C

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Categorías relacionadas

Biochem/physiol Actions

Agonista del purinoceptor P2
Agonista purinérgico P2; aumenta la actividad de los canales de K+ activados por Ca2+; sustrato de los sistemas enzimáticos dependientes de ATP

Application

Adenosine 5γ-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is use in many cellular processes, respiration, biosynthetic reactions, motility, and cell division. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger cAMP. ATP provides the metabolic energy to drive metabolic pumps. ATP serves as a coenzyme in a wide array of enzymatic reactions.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000506528
0000506540
0000506540
0000506528
0000504201

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the water content of Product A7699, Adenosine 5´-triphosphate disodium salt hydrate (ATP)? Does the formula weight listed on the website include water?

    The formula weight on the website does not include water as the amount of water in the product will vary from lot to lot. The water content for any specific lot will be reported on the Certificate of Analysis for that lot.

  4. What is the solubility of Product A7699, Adenosine 5´-triphosphate disodium salt hydrate (ATP)?

    ATP disodium salt is soluble in water (50 mg/mL), yielding a clear, colorless solution. This solution is mildly acidic (pH approximately 3.5).

  5. What is the stability of Product A7699, Adenosine 5´-triphosphate disodium salt hydrate (ATP), in solution?

    Aqueous solutions of ATP are stable for months when frozen at -15°C and for approximately one week at 0°C. ADP is the first hydrolysis product formed, with additional hydrolysis leading to the formation of AMP. However, ATP solutions are only stable for several hours at 0 °C when dissolved in a trichloroacetic acid solution. In alkaline solution, it rapidly decomposes to inorganic pyrophosphate and adenosine 5'-phosphate even at 0 °C. This information can be found on the product information sheet (under Documents, above.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Stefan P Mortensen et al.
The Journal of physiology, 589(Pt 7), 1847-1857 (2011-02-09)
Intraluminal ATP could play an important role in the local regulation of skeletal muscle blood flow, but the stimuli that cause ATP release and the levels of plasma ATP in vessels supplying and draining human skeletal muscle remain unclear. To
Mark W Gorman et al.
American journal of physiology. Heart and circulatory physiology, 299(6), H1981-H1989 (2010-09-21)
The adenine nucleotide hypothesis postulates that the ATP released from red blood cells is broken down to ADP and AMP in coronary capillaries and that ATP, ADP, and AMP act on purinergic receptors on the surface of capillary endothelial cells.
Marc Clement et al.
Arteriosclerosis, thrombosis, and vascular biology, 39(8), 1645-1651 (2019-06-07)
MARK4 (microtubule affinity-regulating kinase 4) regulates NLRP3 (nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain containing 3) inflammasome activation. The aim of the study is to examine the role of MARK4 in hematopoietic cells during atherosclerosis. We show increased MARK4
Alexander Puzenko et al.
The Journal of chemical physics, 137(19), 194502-194502 (2012-11-28)
In this, the third part of our series on the dielectric spectrum symmetrical broadening of water, we consider the nucleotide aqueous solutions. Where in Parts I [E. Levy et al., J. Chem. Phys. 136, 114502 (2012)] and II [E. Levy
Shaima'a Hamarsheh et al.
Nature communications, 11(1), 1659-1659 (2020-04-05)
Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link between oncogenic KrasG12D and NLRP3
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Product Information Sheet - A7699

Product Information Sheet

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