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Merck

A8351

Ampicilina sodium salt

BioXtra, suitable for cell culture

Sinónimos:

D-(−)-α-Aminobencilpenicilina sodium salt

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About This Item

Fórmula empírica (notación de Hill):
C16H18N3NaO4S
Número CAS:
69-52-3
Peso molecular:
371.39
UNSPSC Code:
51281716
NACRES:
NA.76
PubChem Substance ID:
24891335
EC Number:
200-708-1
Beilstein/REAXYS Number:
4119211
MDL number:
MFCD00064313

Nombre del producto

Ampicilina sodium salt, BioXtra, suitable for cell culture

InChI key

KLOHDWPABZXLGI-YWUHCJSESA-M

InChI

1S/C16H19N3O4S.Na/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);/q;+1/p-1/t9-,10-,11+,14-;/m1./s1

SMILES string

[Na+].CC1(C)SC2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C([O-])=O

product line

BioXtra

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white to off-white

mp

215 °C (dec.) (lit.)

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

Quality Level

200

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Categorías relacionadas

Biochem/physiol Actions

Modo de acción: Es un antibiótico ß-lactámico que inhibe la síntesis de la pared celular bacteriana al inactivar las transpeptidasas de la superficie interna de la membrana celular de la bacteria.

Modo de resistencia: La administración con ß-lactamasa rompe el anillo ß-lactámico de la ampicilina y la inactiva.

Espectro antimicrobiano: Incluye bacterias grampositivas (como la bencilpenicilina) y baterías gramnegativas (como las tetraciclinas y el cloranfenicol).

Application

Ampicillin is a semi-synthetic derivative of penicillin that functions as a broad-spectrum antibiotic. It has been used to study antibiotic resistance and penetration limitations, the synergy between multiple antibiotics, certain bloodstream infections, and has been used to develop PCR assays to detect resistance genes in cerebrospinal fluid.

Disclaimer

This product has been reported stable as supplied at 25°C at 43% and 81% relative humidity for six weeks. Additional studies have shown that the stability of Ampicillin in solution is a function of pH, temperature and the identity of the buffer. It′s activity is quickly lost when stored above pH 7. Optimal storage conditions are suggested as 2-8°C, and pH 3.8-5 where its activity was retained at 90%+ for a week.

General description

Chemical structure: ß-lactam

Other Notes

Keep container tightly closed in a dry and well-ventilated place, hygroscopic.

Preparation Note

Ampicillin is reported as slightly soluble in water, practically insoluble in alcohol, chloroform, ether and fixed oils but soluble in dilute acids or bases. The solution should not be autoclaved; a stock solution should be sterilized through filtration and stored frozen, where it will be stable for months.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1A - Skin Sens. 1A

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
0000521855
0000521857
0000511777
0000521855
0000521857

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