C104
(±)-CPP
solid
Sinónimos:
(±)-3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid
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Fórmula empírica (notación de Hill):
C8H17N2O5P
Número CAS:
Peso molecular:
252.20
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Servicio técnico
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solid
Quality Level
color
white
solubility
H2O: 99.2 mg/mL, ethanol: insoluble
SMILES string
OC(=O)C1CN(CCCP(O)(O)=O)CCN1
InChI
1S/C8H17N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h7,9H,1-6H2,(H,11,12)(H2,13,14,15)
InChI key
CUVGUPIVTLGRGI-UHFFFAOYSA-N
Gene Information
human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)
rat ... Grin2a(24409)
Application
(±)-CPP has been used as an uncompetitive NMDA receptor antagonist:
- to study its effects on blood glucose in mice
- in electrophysiological recording in mouse brain slices
- in electrophysiological recording in rat hippocampal pyramidal neurons
Biochem/physiol Actions
3-(2-carboxypiperazin-4yl) propyl-1-phosphonic acid (CPP) is a potent, competitive, and selective N-methyl-D-aspartate (NMDA) receptor antagonist. It is an analog of 2-amino-7-phosphonoheptanoic acid. CPP shows anticonvulusant and antinociceptive activity.
Disclaimer
Hygroscopic
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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