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Merck

C4490

Anti-Caveolin-1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-Caveolin-1, Anti-VIP21

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UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD01633097
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB
Citations:
17

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 22 kDa

species reactivity

human, rat, mouse

technique(s)

indirect immunofluorescence: 4-8 μg/mL using HUVEC cell line, indirect immunofluorescence: suitable, western blot: 1-2 μg/mL using whole cell extract of the human endothelial ECV304 cell line and the mouse fibroblast NIH3T3 cell line

UniProt accession no.

Q03135

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... CAV1(857)
mouse ... Cav1(12389)
rat ... Cav1(25404)

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General description

Caveolin, a 20-24 kDa integral transmembrane protein, has been identified as a principal component of caveolae membranes. Caveolin (also termed VIP21) exists in several isoforms termed caveolin-1, caveolin-2 and caveolin-3. Caveolin-1 (CAV1) (20- 22 kDa) can exist as two isoforms, caveolin-1α and -1β due to alternative splicing of the mRNA. Caveolin-1 and -2 have similar tissue distribution.

Immunogen

synthetic peptide corresponding to a region at the N-terminus of human caveolin-1 (amino acids 2-20).

Application

Anti-Caveolin-1 antibody produced in rabbit has been used in:
  • immunoblotting
  • immunofluorescence
  • immunohistochemistry

Biochem/physiol Actions

Caveolin can simultaneously recognize GPI-linked proteins and interact directly with a number of caveolae associated downstream signaling molecules, such as H-Ras, hetero-trimeric G-proteins, annexin-II, epidermal growth factor receptor (EGFR), protein kinase C, src-family tyrosine kinases and nitric oxide synthase (NOS) isoforms. Caveolin-1 participates in angiogenesis and is expected to play a major role in the growth and evolution of cancer. It participates in glucose metabolism by controlling the expression of glucose transporters.
The sequence is highly conserved in many species, e.g., identical in rat, mouse, bovine, and dog caveolin-1. The sequence is not found in caveolin-2 or caveolin-3.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Clase de almacenamiento

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000242785
0000242785
0000148600
0000148600
0000158695

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Brian C Russo et al.
mBio, 10(3) (2019-05-30)
Many Gram-negative bacterial pathogens require a type 3 secretion system (T3SS) to deliver effector proteins into eukaryotic cells. Contact of the tip complex of the T3SS with a target eukaryotic cell initiates secretion of the two bacterial proteins that assemble
Ingrid R Niesman et al.
Molecular and cellular neurosciences, 56, 283-297 (2013-07-16)
Microglia are ramified cells that serve as central nervous system (CNS) guardians, capable of proliferation, migration, and generation of inflammatory cytokines. In non-pathological states, these cells exhibit ramified morphology with processes intermingling with neurons and astrocytes. Under pathological conditions, they
Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes
Yun JH, et al.
Experimental & Molecular Medicine, 43(12), 660-660 (2011)
Study of caveolin-1 gene expression in whole adipose tissue and its subfractions and during differentiation of human adipocytes
Fernandez RJM, et al.
Nutrition & Metabolism, 7(1), 20-20 (2010)
Masashi Ogasawara et al.
Acta neuropathologica communications, 10(1), 176-176 (2022-12-09)
Oculopharyngodistal myopathy (OPDM) and oculopharyngeal muscular dystrophy (OPMD) are similar and even believed to be indistinguishable in terms of their myopathological features. To address the diagnostic gap, we evaluated the muscle biopsy samples for p62 expression by immunohistochemistry and compared
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