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Merck

C5135

Castor Oil, Ethoxylated

pH range 6.0-8.0

Sinónimos:

Cremophor® EL, EL, Macrogolglycerol ricinoleate, PEG-35 castor oil, Polyoxyl-35 castor oil

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Número CAS:
UNSPSC Code:
12161902
NACRES:
NA.25
MDL number:
Servicio técnico
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description

non-ionic

Quality Level

form

liquid

mol wt

~2500 g/mol

pH range

6.0-8.0

HLB

12 - 14

application(s)

sample preservation

SMILES string

ClCC(OC(=O)N)CCl

InChI

1S/C4H7Cl2NO2/c5-1-3(2-6)9-4(7)8/h3H,1-2H2,(H2,7,8)

InChI key

JMNCUXPHXKHBPY-UHFFFAOYSA-N

General description

Castor Oil, Ethoxylated is a nonionic solubilizer and emulsifier made by reacting castor oil with ethylene oxide. It is a pale yellow oily liquid that is clear at temperatures above 26°C. It has a faint but characteristic odour.
Castor Oil, Ethoxylated is polyethylene oxide surfactant and is viscous in nature. It has a hydrophobic-lipophilic balance value in the range of 12-14.

Application

Castor Oil, Ethoxylated has been used as a detergent to improve the solubility of dye and to increase the transmembrane permeation. It has been used as a vehicle for drug/stimulant delivery in cells.

Biochem/physiol Actions

Castor Oil, Ethoxylated is used in lipid-based formulations for drugs and solubilization of cosmetics. Castor Oil, Ethoxylated is suitable for the production of semi-solid and liquid formulations of water-insoluble actives and other hydrophobic compounds. Due to its emulsification functionality, it finds application in biological membrane- based drug transport studies.

Other Notes

A derivative of castor oil and ethylene oxide.

Legal Information

Cremophor is a registered trademark of BASF SE


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Clase de almacenamiento

10 - Combustible liquids

flash_point_f

494.6 °F - Not applicable

flash_point_c

257 °C - Not applicable

ppe

Eyeshields, Gloves



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Timek T
The Annals of Thoracic Surgery, 66, 1618-1618 (1998)
Colloidal nanocarriers for the enhanced cutaneous delivery of naftifine: characterization studies and in vitro and in vivo evaluations
Erdal MS, et al.
International journal of nanomedicine, 11, 1027-1027 (2016)
A nonionic polyethylene oxide (PEO) surfactant model: experimental and molecular dynamics studies of Kolliphor EL
Suys EJA, et al.
Journal of Pharmaceutical Sciences, 108(1), 193-204 (2019)