C5423

Clenbuterol hydrochloride

Name: Clenbuterol hydrochloride
Brand: SIGMA

≥95% (TLC), powder, β2-adrenoceptor agonist

Sinónimos:

4-Amino-α-(t-butylaminomethyl)-3,5-dichlorobenzyl alcohol hydrochloride

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About This Item

Fórmula empírica (notación de Hill):

C₁₂H₁₈Cl₂N₂O · HCl

Número CAS:

21898-19-1

Peso molecular:

313.65

NACRES:

NA.77

PubChem Substance ID:

24892782

UNSPSC Code:

12352200

EC Number:

244-643-7

MDL number:

MFCD00083280

Nombre del producto

Clenbuterol hydrochloride, ≥95%

InChI

1S/C12H18Cl2N2O.ClH/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7;/h4-5,10,16-17H,6,15H2,1-3H3;1H

InChI key

OPXKTCUYRHXSBK-UHFFFAOYSA-N

SMILES string

Cl.CC(C)(C)NCC(O)c1cc(Cl)c(N)c(Cl)c1

assay

≥95%

form

powder

drug control

Home Office Schedule 4.2

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... ADRB2(154)

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Categorías relacionadas

Bioactive Small Molecule Agonists

Bioactive Small Molecules

Application

Clenbuterol hydrochloride has been used:

as an agonist for β-adrenergic receptor (β-AR) from chick skeletal muscle
to induce hypertrophic effects in masseter, digastric, and temporalis muscles of rat
as a reference β-agonist standard in tandem mass spectrometry(MS-MS)

Biochem/physiol Actions

Clenbuterol hydrochloride is a β2-adrenoceptor agonist and bronchodilator. It is effective in improving peak expiratory flow rate (PEFR) in asthma patients. Clenbuterol is also a performance-enhancing drug as it stimulates the central nervous system and improves oxygen transport. Clenbuterol elicits cardio protective functionality in patients with dilated cardiomyopathy.

pictograms

GHS08

signalword

Danger

hcodes

H351,H360FD

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Carc. 2 - Repr. 1B

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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A trial of clenbuterol in bronchial asthma.

Anderson G and Wilkins E

Thorax, 32(6), 717-719 (1977)

The beta-adrenoceptor agonist clenbuterol is a potent inhibitor of the LPS-induced production of TNF-alpha and IL-6 in vitro and in vivo.

C A Izeboud et al.

Inflammation research : official journal of the European Histamine Research Society ... [et al.], 48(9), 497-502 (1999-10-16)

To investigate the suppressive effects of the beta-agonist clenbuterol on the release of TNF-alpha and IL-6 in a lipopolysaccharide (LPS)-model of inflammation, both in vitro and in vivo. Human U-937 cell line (monocyte-derived macrophages), and male Wistar rats (200-250 g).

Systemic administration of a β2-adrenergic receptor agonist reduces mechanical allodynia and suppresses the immune response to surgery in a rat model of persistent post-incisional hypersensitivity.

Vipin Arora et al.

Molecular pain, 17, 1744806921997206-1744806921997206 (2021-04-09)

Beta 2 adrenergic receptor (β2 AR) activation in the central and peripheral nervous system has been implicated in nociceptive processing in acute and chronic pain settings with anti-inflammatory and anti-allodynic effects of β2-AR mimetics reported in several pain states. In

beta2-adrenoceptor agonist clenbuterol reduces infarct size and myocardial apoptosis after myocardial ischaemia/reperfusion in anaesthetized rats

Zhang Q, et al.

British Journal of Pharmacology, 160(6), 1561-1572 (2010)

Effects of clenbuterol, a beta2-adrenergic agonist, on sizes of masseter, temporalis, digastric, and tongue muscles

Ishikawa C, et al.

The Open Dentistry Journal, 3, 191-191 (2009)

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