C9033
β-Chloro-L-alanine hydrochloride
Alanine aminotransferase inhibitor
Sinónimos:
(R)-2-Amino-3-chloropropanoic acid, 3-Chloro-L-alanine
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Fórmula empírica (notación de Hill):
C3H6ClNO2 · HCl
Número CAS:
Peso molecular:
160.00
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
Servicio técnico
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Permítanos ayudarlebiological source
synthetic
Quality Level
assay
≥98% (TLC)
form
powder
mp
205 °C
solubility
water: 50 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
Cl[H].N[C@@H](CCl)C(O)=O
InChI
1S/C3H6ClNO2.ClH/c4-1-2(5)3(6)7;/h2H,1,5H2,(H,6,7);1H/t2-;/m0./s1
InChI key
IENJPSDBNBGIEL-DKWTVANSSA-N
Application
β-Chloro-L-alanine hydrochloride has been used:
- as a substrate for screening tyrosine phenol lyase steady state kinetics
- in the inhibition of serine palmitoyltransferase and cytotoxicity studies in lymphocyte Ly-1 cells
- as an inhibitor of alanine transaminase in wheat germ cell-free protein synthesis system
Biochem/physiol Actions
β-Chloro-L-alanine hydrochloride is an inhibitor of alanine aminotransferase (ALAT). Inhibition of ALAT leads to suppression of tumor progression in lung carcinoma.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Oxytetracycline have the therapeutic efficiency in CD133+ HCC population through suppression CD133 expression by decreasing of protein stability of CD133
Song Y, et al.
Scientific Reports, 8(1), 16100-16100 (2018)
Specificity of inhibitors of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis, in intact cells: a novel evaluation system using an SPT-defective mammalian cell mutant
Hanada K, et al.
Biochemical Pharmacology, 59(10), 1211-1216 (2000)
Inhibition of alanine aminotransferase (ALAT) in silico and in vivo promotes mitochondrial metabolism to impair malignant growth
Beuster G, et al.
The Journal of Biological Chemistry, jbc-M110 (2011)