C9819
Chondroitin sulfate A sodium salt from bovine trachea
lyophilized powder, BioReagent, suitable for cell culture
Sinónimos:
Alternating Copoly β-glucuronic acid-(1→3)-N-acetyl-β-galactosamine-4-sulfate-(1→4)
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Acerca de este artículo
Biological source:
bovine trachea
Form:
lyophilized powder
Technique(s):
cell culture | mammalian: suitable
Servicio técnico
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Permítanos ayudarlebiological source
bovine trachea
product line
BioReagent
form
lyophilized powder
packaging
poly bottle of 25 g, poly bottle of 5 g
technique(s)
cell culture | mammalian: suitable
surface coverage
20‑2000 μg/cm2
shipped in
ambient
storage temp.
2-8°C
Quality Level
Application
Chondroitin appears to play a regulatory role for chondrocytes, neural cells, and some tumor cells. Chondroitin sulfate B is used to study β peptide (1-42) cytotoxicity.
Biochem/physiol Actions
As a large, negatively charged, hydrophilic molecule that is too inflexible to fold into a compact globular structure, chondroitin sulfate molecules form porous hydrated gels, providing mechanical support to tissue and allowing rapid diffusion of water-soluble molecules and migration of cells.
Preparation Note
This product is soluble in water at 100 mg/mL.
Other Notes
Chondroitin Sulfate A is an acidic mucopolysaccharide found in cartilage, skin, cornea, and umbilical cord. It is composed of alternating N-acetylgalactosamine, D-glucuronic acid, and sulfate residues in equimolar quantities where carbon 4 of the N-acetylgalactosamines is sulfated.
Disclaimer
Store this product at 2-8°C.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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In placental malaria, Plasmodium falciparum-infected erythrocytes adhere to the apical plasma membrane of the placental epithelium, triggering an impairment of placental function detrimental to the fetus. The design of anti-adhesion intervention strategies requires a detailed understanding of the mechanisms involved.
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Osteoarthritis (OA) is a progressive, chronic disease characterized by articular cartilage destruction. The pro-inflammatory cytokine IL-17 levels have been reported elevated in serum and synovial fluid of OA patients and correlated with increased cartilage defects and bone remodeling. The aim
Tomomi Izumikawa et al.
Biochimica et biophysica acta, 1830(10), 4806-4812 (2013-07-03)
Previously, we identified two missense mutations in the chondroitin N-acetylgalactosaminyltransferase-1 gene in patients with neuropathy. These mutations are associated with a profound decrease in chondroitin N-acetylgalactosaminyltransferase-1 enzyme activity. Here, we describe a patient with neuropathy who is heterozygous for a
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