D1156
N,N-Dimethylglycine
≥99%, suitable for ligand binding assays
Sinónimos:
(Dimethylamino)acetic acid
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Fórmula lineal:
(CH3)2NCH2COOH
Número CAS:
Peso molecular:
103.12
NACRES:
NA.26
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
214-267-8
MDL number:
Beilstein/REAXYS Number:
1700261
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Permítanos ayudarleNombre del producto
N,N-Dimethylglycine, ≥99%
Quality Level
assay
≥99%
form
powder
technique(s)
ligand binding assay: suitable
color
white to off-white
mp
178-182 °C (lit.)
application(s)
peptide synthesis
SMILES string
CN(C)CC(O)=O
InChI
1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7)
InChI key
FFDGPVCHZBVARC-UHFFFAOYSA-N
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Biochem/physiol Actions
N,N-Dimethylglycine (DMG) is a natural N-methylated glycine that is used in comparative analysis with other N-methylated glycines such as sarcosine and βine. N,N-Dimethylglycine is used in the development of glycine-based ionic liquids and emulsifiers. N,N-Dimethylglycine is potentially useful as a biomarker of protein degradation in COPD patients. DMG is used as a substrate to identify, differentiate and characterize amino acid methyltransferase(s).
Clase de almacenamiento
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Baljit K Ubhi et al.
The European respiratory journal, 40(2), 345-355 (2011-12-21)
There is a paucity of biomarkers for chronic obstructive pulmonary disease (COPD). Metabolomics were applied to a defined COPD patient cohort from the ECLIPSE study (Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points). Results were correlated with accepted biomarkers
B A Binzak et al.
American journal of human genetics, 68(4), 839-847 (2001-03-07)
Dimethylglycine dehydrogenase (DMGDH) (E.C. number 1.5.99.2) is a mitochondrial matrix enzyme involved in the metabolism of choline, converting dimethylglycine to sarcosine. Sarcosine is then transformed to glycine by sarcosine dehydrogenase (E.C. number 1.5.99.1). Both enzymes use flavin adenine dinucleotide and
S H Moolenaar et al.
Clinical chemistry, 45(4), 459-464 (1999-04-02)
A38-year-old man presented with a history of fish odor (since age 5) and unusual muscle fatigue with increased serum creatine kinase. Our aim was to identify the metabolic error in this new condition. We used 1H NMR spectroscopy to study
Sheila M Innis et al.
The American journal of clinical nutrition, 93(3), 564-568 (2011-01-14)
Choline is an important constituent of acetylcholine. Choline is needed for acetylcholine in the nonneuronal acetylcholine system that includes epithelial cells of the lung and intestine, endothelial cells, and immune cells. Plasma free choline concentrations are low in children with
Jian Yan et al.
The American journal of clinical nutrition, 95(5), 1060-1071 (2012-03-16)
In 1998 choline Adequate Intakes of 425 and 450 mg/d were established for nonpregnant and pregnant women, respectively. However, to our knowledge, no dose-response studies have been conducted to evaluate the effects of pregnancy or maternal choline intake on biomarkers
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