E2758

β-Estradiol

Name: β-Estradiol
Brand: SIGMA

BioReagent, powder, suitable for cell culture

Sinónimos:

1,3,5-Estratriene-3,17β-diol, 17β-Estradiol, 3,17β-Dihydroxy-1,3,5(10)-estratriene, Dihydrofolliculin

Iniciar sesión para ver los precios por organización y contrato.

Seleccione un Tamaño

Todas las fotos(6)

About This Item

Fórmula empírica (notación de Hill):

C₁₈H₂₄O₂

Número CAS:

50-28-2

Peso molecular:

272.38

UNSPSC Code:

12352209

NACRES:

NA.77

PubChem Substance ID:

24894483

EC Number:

200-023-8

Beilstein/REAXYS Number:

1914275

MDL number:

MFCD00003693

biological source:

synthetic (organic)

form:

powder

assay:

≥98% (HPLC)

Nombre del producto

β-Estradiol, BioReagent, powder, suitable for cell culture

InChI key

VOXZDWNPVJITMN-ZBRFXRBCSA-N

InChI

1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

SMILES string

O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C

biological source

synthetic (organic)

product line

BioReagent

assay

≥98% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable
single cell analysis: suitable

mp

176-180 °C (lit.)

solubility

ethanol: 50 mg/mL, clear, colorless

shipped in

ambient

storage temp.

room temp

Quality Level

200

Gene Information

human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), GPER(2852), SERPINA6(866)
mouse ... Esr1(13982), Esr2(13983), Esrra(26379)
rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775)

¿Está buscando productos similares? Visita Guía de comparación de productos

Biochem/physiol Actions

The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.

β-Estradiol (E2) is a major premenopausal hormone in women and is essential for spermiogenesis, sperm maturation and motility in men. Cultured bone marrow stem cells (BMSCs) have ability to synthesize E2 and could be exploited for treating estrogen deficiency. It mediates physiological functions through estrogen receptor (ER) α and ERβ.

The major estrogen secreted by the premenopausal ovary.

Application

β-Estradiol has been used:

as a component of Dulbecco′s modified Eagle medium (DMEM) for culturing mammary tumor cells
as a oestrogenic compound for testing neuroprotective effects
as a component of medium199 for culturing oocytes

β-Estradiol is used to study cell differentiation and transformations (tumorigenicity).

General description

β-Estradiol or estradiol-17 β (E2) is secreted majorly by the large preovulatory follicles in the ovary. In addition, estradiol can be synthesized de novo from cholesterol have androgens synthesized from cholesterol. The aromatization of androgen by enzyme aromatase (P450arom) results in the β-estradiol production.

Physical form

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Preparation Note

To prepare a 20 μg/ml stock solution, add 1 ml absolute ethanol to 1 mg β-estradiol; gently swirl to dissolve; add 49 ml sterile medium while mixing.

pictograms

GHS08,GHS09

signalword

Danger

hcodes

H351,H360FD,H362,H410

pcodes

P202 - P260 - P263 - P264 - P273 - P308 + P313

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Estradiol synthesis and release in cultured female rat bone marrow stem cells

Zhang D, et al.

BioMed Research International, 2013 (2013)

The developmental potential of oocytes is impaired in cattle with liver abnormalities

Sarentonglaga B, et al.

Journal of Reproduction and Development, 59(2), 168-173 (2013)

Estrogen synthesis and signaling pathways during aging: from periphery to brain

Cui J, et al.

Trends in Molecular Medicine, 19(3), 197-209 (2013)

Selective oestrogen receptor (ER) modulators reduce microglia reactivity in vivo after peripheral inflammation: potential role of microglial ERs

Tapia-Gonzalez S, et al.

The Journal of Endocrinology, 198, 219?230-219?230 (2008)

Loss of STAT1 from mouse mammary epithelium results in an increased Neu-induced tumor burden

Klover PJ, et al.

Neoplasia, 12(11), 899-905 (2010)

Ver todos los artículos relacionados

Contenido relacionado

Biochemical Solubility Product Information - E2758

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico