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Merck

F0287

Fibronectina

lyophilized powder, 70 kDa

Sinónimos:

Fibronectin

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About This Item

UNSPSC Code:
12352202
eCl@ss:
42020141
NACRES:
NA.75
MDL number:
MFCD00131062

Nombre del producto

Fibronectina, lyophilized powder, 70 kDa

biological source

human plasma

assay

>90% (SDS-PAGE)

form

lyophilized powder

mol wt

70 kDa

packaging

pkg of 0.5 mg

technique(s)

cell culture | mammalian: suitable

impurities

HIV and HBsAg, source material tested negative
 Small proteolytic fragments, may contain traces

solubility

water: soluble ≥0.500 mg/mL, clear to slightly hazy, colorless

UniProt accession no.

P02751

shipped in

ambient

storage temp.

−20°C

Quality Level

200

Gene Information

human ... FN1(2335)

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Application

Fibronectin Proteolytic Fragment from human plasma has been used in pre adsorbed antibody blocking assay and EC-pericyte tube coassembly.

Biochem/physiol Actions

Fibronectin participates in cell adhesion, growth, migration, wound healing, blood coagulation and metastasis. Mutations in FN1 results in glomerulopathy. It plays an important role in cell attachment and spreading, control of cell cytoskeleton, morphology and differentiation. FN1 is also involved in extracellular matrix formation, hemostasis and thrombosis. Proteolytic fragments of fibronectin plays a vital role in mononuclear phagocyte function.

Disclaimer

The product should be stored at -20°C.

General description

Fibronectin 1 is a glycoprotein of the extracellular matrix that is coded by FN1 gene. It is expressed in the plasma and at the cell surface. FN1 is mapped to human chromosome 2q35. Proteolytic fragments of fibronectin has a cell binding domain.

Preparation Note

This product is lyophilized from phosphate buffered saline with sucrose as a cryoprotectant. The source material has tested negative for antibody to HIV, HCN, and HBsAg. It is soluble in water at 0.5 mg/mL and yields a clear to slightly hazy solution.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
079M4076V
11190206
058M4155V
11171235
065M4052V

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Visite la Librería de documentos

C Penn et al.
Microbial pathogenesis, 17(6), 387-393 (1994-12-01)
Candida albicans yeast cells bind soluble human plasma fibronectin (Fn) through a glycoprotein receptor (adhesin) located on the cell surface. This work demonstrates that a 120 kDa proteolytic fragment of Fn encompassing the cell binding domain binds more avidly to
Fibronectin in Health and Disease (2018)
Mutations F352A and Y528A in human HSP90I? reduce fibronectin association and fibrillogenesis in cell-derived matrices.
Chakraborty, et al.
Cell Stress & Chaperones (2023)
Ail protein binds ninth type III fibronectin repeat (9FNIII) within central 120 kDa region of fibronectin to facilitate cell binding by Yersinia pestis.
Tsang T M, et al.
The Journal of Biological Chemistry, 287(20), 16759-16767 (2012)
Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation.
Stratman A N, et al.
Blood, 114(24), 5091-5101 (2009)
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