G8541
Ala-Gln
200 mM, solution, sterile-filtered, Biotechnology Performance Certified
Sinónimos:
Alanyl-glutamine, Glutamine-S
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Fórmula empírica (notación de Hill):
C8H15N3O4
Número CAS:
Peso molecular:
217.22
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.75
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Permítanos ayudarleSMILES string
NC(CC[C@H](NC([C@@H](N)C)=O)C(O)=O)=O
InChI
1S/C8H15N3O4/c1-4(9)7(13)11-5(8(14)15)2-3-6(10)12/h4-5H,2-3,9H2,1H3,(H2,10,12)(H,11,13)(H,14,15)/t4-,5-/m0/s1
InChI key
HJCMDXDYPOUFDY-WHFBIAKZSA-N
grade
Biotechnology Performance Certified
sterility
sterile-filtered
form
solution
concentration
200 mM
impurities
endotoxin, tested
storage temp.
2-8°C
Quality Level
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General description
Ala-Gln supplement provides a stable form of L-glutamine while in solution.
Application
Ala-Gln has been used as a supplement in Dulbecco′s Modified Eagle Medium (DMEM) media-rich in glucose and pyruvate to culture luciferase-expressing MDA-MB-231-luc tumor cells to measure the bioluminescence signals of cells leaking during intra-bone marrow transplantation (IBMT) from dissected long bones. It has also been used as a DMEM - high glucose media to culture human cell lines.
Other Notes
Contains the dipeptide L-Alanyl-L-glutamine. 200 mM supplied in 0.85% NaCl.
Clase de almacenamiento
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Dieter Fink et al.
PloS one, 14(11), e0224576-e0224576 (2019-11-08)
Intra-bone marrow transplantation (IBMT) has been adapted for mouse models to improve the seeding efficiency of transplanted hematopoietic stem and progenitor cells. Commonly used injection volumes for IBMT into the tibia differ between 10 and 40 μL even though considerable
Daren K Heyland et al.
JPEN. Journal of parenteral and enteral nutrition, 39(4), 401-409 (2014-05-08)
The recent large randomized controlled trial of glutamine and antioxidant supplementation suggested that high-dose glutamine is associated with increased mortality in critically ill patients with multiorgan failure. The objectives of the present analyses were to reevaluate the effect of supplementation
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Nature biotechnology, 39(7), 825-835 (2021-04-14)
In contrast to single-cell approaches for measuring gene expression and DNA accessibility, single-cell methods for analyzing histone modifications are limited by low sensitivity and throughput. Here, we combine the CUT&Tag technology, developed to measure bulk histone modifications, with droplet-based single-cell
Shaoquan Lin et al.
Nature chemistry, 13(1), 47-55 (2020-12-24)
Polyether ionophores are complex natural products capable of transporting cations across biological membranes. Many polyether ionophores possess potent antimicrobial activity and a few selected compounds have the ability to target aggressive cancer cells. Nevertheless, ionophore function is believed to be
Spyridon T Pachis et al.
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Faithful chromosome segregation relies on the ability of the spindle assembly checkpoint (SAC) to delay anaphase onset until chromosomes are attached to the mitotic spindle via their kinetochores. MPS1 kinase is recruited to kinetochores to initiate SAC signaling and is
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