H7250
Histamine dihydrochloride
≥99% (TLC), powder, endogenous histamine receptor agonist
Sinónimos:
2-(4-Imidazolyl)ethylamine dihydrochloride
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Fórmula empírica (notación de Hill):
C5H9N3 · 2HCl
Número CAS:
Peso molecular:
184.07
NACRES:
NA.77
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352116
EC Number:
200-298-4
MDL number:
Beilstein/REAXYS Number:
3624116
Servicio técnico
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Permítanos ayudarleNombre del producto
Histamine dihydrochloride, ≥99% (TLC), powder
Quality Level
assay
≥99% (TLC)
form
powder
color
white to off-white
mp
249-252 °C (lit.)
storage temp.
2-8°C
SMILES string
Cl[H].Cl[H].NCCc1c[nH]cn1
InChI
1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H
InChI key
PPZMYIBUHIPZOS-UHFFFAOYSA-N
Gene Information
human ... HRH1(3269), HRH2(3274)
General description
Histamine dihydrochloride is a derivative of histamine. It prevents the formation of ROS (reactive oxygen species), which inhibits the activation of T cells and natural killer cells. Histamine dihydrochloride is implicated in tumor cell apoptosis. It prevents the relapse of acute myeloid leukemia in patients.
Application
Histamine dihydrochloride has been used:
- as a orthograde cotransmitter in producing excitatory postsynaptic potential (EPSP)
- to determine its level in fish using HPLC (high performance liquid chromatography)
- to assess the tracheal response to antigens in guinea-pigs
Biochem/physiol Actions
Endogenous H1 and H2 histamine receptor agonist; activates nitric oxide synthetase; potent vasodilator.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Maternal dietary antigens and the immune response in the offspring of the guinea-pig.
Telemo E, et al.
Immunology, 62(1), 35-35 (1987)
Determination of some quality criteria of cold storaged marinated anchovy under vacuum and modified atmosphere conditions
Guncsen U, et al.
Turkish Journal of Fisheries and Aquatic Sciences, 11(2), 282-291 (2011)
Immunotherapy with histamine dihydrochloride for the prevention of relapse in acute myeloid leukemia
Martner A, et al.
Expert Review of Hematology, 3(4), 381-391 (2010)