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Merck

I6504

(−)-Isoproterenol hydrochloride

≥98% (TLC), powder, β-adrenoceptor agonist

Sinónimos:

(−)-Isoprenaline hydrochloride, (−)-N-Isopropyl-L-noradrenaline hydrochloride, (R)-3,4-Dihydroxy-α-(isopropylaminomethyl)benzyl alcohol hydrochloride

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About This Item

Fórmula lineal:
3,4-(HO)2C6H3CH(OH)CH2NHCH(CH3)2·HCl
Número CAS:
5984-95-2
Peso molecular:
247.72
NACRES:
NA.77
PubChem Substance ID:
24278495
UNSPSC Code:
12352200
MDL number:
MFCD00064548
Beilstein/REAXYS Number:
6077193

Nombre del producto

(−)-Isoproterenol hydrochloride,

InChI

1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H/t11-;/m0./s1

SMILES string

Cl[H].CC(C)NC[C@H](O)c1ccc(O)c(O)c1

InChI key

IROWCYIEJAOFOW-MERQFXBCSA-N

mp

175 °C (dec.) (lit.)

solubility

soluble (50 mg/ml: H2O)

storage temp.

−20°C

Quality Level

200

Gene Information

human ... ADRB2(154)

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Application

(−)-Isoproterenol hydrochloride has been used in in vitro explant culture. It has also been used in transcriptome analysis of heart.

Biochem/physiol Actions

β-adrenoceptor agonist; increases cytosolic cAMP.
Isoproterenol hydrochloride is useful in post transplantal organ recovery. It exhibits ionotropic and chronotropic effects. With respect to donor heart recovery, isoproterenol hydrochloride decreases peripheral and systemic vascular resistance. Isoproterenol also increases the heart rate.

Preparation Note

This material can be dissolved in 50 mg/ml of H2O.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
0000499683
0000499682
0000499681
0000499681
0000499682

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What can be used to make a solution of (-)-Isoproterenol hydrochloride, Product I6504?

    We test the solubility of (-)-Isoproterenol hydrochloride in water at a concentration of 50 mg/mL. Isoproterenol hydrochloride is also soluble in ethanol at 20 mg/mL.

  6. Can I use a brownish-pink solution of (-)-Isoproterenol hydrochloride, Product I6504?

    Aqueous solutions become pink to brownish-pink when exposed to air, and almost immediately so when made alkaline. This color change indicates degradation.

  7. How should (-)-Isoproterenol hydrochloride, Product I6504, be stored?

    (-)-Isoproterenol hydrochloride is a powder that needs to be stored at -20°C.

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Anne-Marie Schönegge et al.
Nature communications, 8(1), 2169-2169 (2017-12-20)
Functional selectivity of G-protein-coupled receptors is believed to originate from ligand-specific conformations that activate only subsets of signaling effectors. In this study, to identify molecular motifs playing important roles in transducing ligand binding into distinct signaling responses, we combined in
Acute Care Handbook for Physical Therapists, 414-414 (2008)
Michael H Lai et al.
American journal of physiology. Heart and circulatory physiology, 307(9), H1327-H1338 (2014-08-31)
Large-conductance Ca(2+)- and voltage-activated K(+) (BK) channels play prominent roles in shaping muscle and neuronal excitability. In the cardiovascular system, BK channels promote vascular relaxation and protect against ischemic injury. Recently, inhibition of BK channels has been shown to lower
Seon Jin Lee et al.
Stem cells international, 2018, 7453161-7453161 (2018-12-05)
Cross talks between the renin-angiotensin system (RAS), sympathetic nervous system, and vascular homeostasis are tightly coordinated in hypertension. Angiotensin II (Ang II), a key factor in RAS, when abnormally activated, affects the number and bioactivity of circulating human endothelial progenitor
Influence of adipocyte size and adipose depot on the in vitro lipolytic activity and insulin sensitivity of adipose tissue in dairy cows at the end of the dry period
De Koster J, et al.
Journal of Dairy Science, 99(3), 2319-2328 (2016)
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