L135

L-741,626

Name: L-741,626
Brand: SIGMA

≥98% (HPLC)

Sinónimos:

(±)-3-[4-(4-Chlorophenyl)-4-hydroxypiperidinyl]methylindole

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Fórmula empírica (notación de Hill):

C₂₀H₂₁ClN₂O

Número CAS:

81226-60-0

Peso molecular:

340.85

NACRES:

NA.77

PubChem Substance ID:

24278529

UNSPSC Code:

12352200

MDL number:

MFCD00953632

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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InChI

1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2

SMILES string

OC1(CCN(CC1)Cc2c[nH]c3ccccc23)c4ccc(Cl)cc4

InChI key

LLBLNMUONVVVPG-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥20 mg/mL, ethanol: 24 mg/mL, H₂O: insoluble

storage temp.

room temp

Quality Level

100

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815)

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Application

L-741,626 has been used as selective dopamine (D₂) receptor antagonist to study its effects on the uptake of dopamine in human embryonic kidney 293 (HEK293) cells. It has also been used as a D₂ receptor antagonist to study its effects on thyrotropin-releasing hormone (TRH) induced prolactin release.

Biochem/physiol Actions

L-741,626 is a selective dopamine (D₂) receptor antagonist.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number

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Visite la Librería de documentos

Antagonism of the effects of (+)-PD 128907 on midbrain dopamine neurones in rat brain slices by a selective D2 receptor antagonist L-741,626.

B J Bowery et al.

British journal of pharmacology, 119(7), 1491-1497 (1996-12-01)

1. The ability of PD 128907 to activate dopamine receptors in the ventral tegmental area, substantia nigra pars compacta, and striatum was investigated by use of in vitro electrophysiological recording and fast cyclic voltammetry. The affinity of a novel D2

Blockade of dopamine D(3) receptors in frontal cortex, but not in sub-cortical structures, enhances social recognition in rats: similar actions of D(1) receptor agonists, but not of D(2) antagonists.

Florence Loiseau et al.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 19(1), 23-33 (2008-09-17)

Though D(3) receptor antagonists can enhance cognitive function, their sites of action remain unexplored. This issue was addressed employing a model of social recognition in rats, and the actions of D(3) antagonists were compared to D(1) agonists that likewise possess

D2 Dopamine receptor subtype mediates the inhibitory effect of dopamine on TRH-induced prolactin release from the bullfrog pituitary.

Masaki Nakano et al.

General and comparative endocrinology, 168(2), 287-292 (2010-06-18)

Dopamine receptors in mammals are known to consist of two D1-like receptors (D1 and D5) and three D2-like receptors (D2, D3 and D4). The aim of this study was to determine the dopamine receptor subtype that mediates the inhibitory action

PREX1 integrates G protein-coupled receptor and phosphoinositide 3-kinase signaling to promote glioblastoma invasion.

Alexander Gont et al.

Oncotarget, 8(5), 8559-8573 (2017-01-05)

A defining feature of the brain cancer glioblastoma is its highly invasive nature. When glioblastoma cells are isolated from patients using serum free conditions, they accurately recapitulate this invasive behaviour in animal models. The Rac subclass of Rho GTPases has

Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors.

F Chaperon et al.

Neuropharmacology, 44(8), 1047-1053 (2003-05-24)

The dopamine D(3) receptor agonist PD 128907 decreased body temperature in the rat. The selective dopamine D(3) and D(4) receptor antagonists, A-437203 and L-745,870, respectively, did not prevent this effect. In contrast, PD 128907-induced hypothermia was antagonized by SCH 23390

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L-741,626

≥98% (HPLC)

Seleccione un Tamaño

Acerca de este artículo

Documentos clave

Propiedades

InChI

SMILES string

InChI key

assay

form

color

solubility

storage temp.

Quality Level

Gene Information

Descripción

Application

Biochem/physiol Actions

Features and Benefits

Información de seguridad

Clase de almacenamiento

wgk

flash_point_f

flash_point_c

ppe

Documentación

Certificados de análisis (COA)

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Artículos con revisión científica externa.

Servicio técnico