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Merck

L3908

ββ-Lactoglobulina from bovine milk

≥90% (PAGE), lyophilized powder

Sinónimos:

βLg, BLG, Bos d 5, beta-lactoglobulin

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Número CAS:
UNSPSC Code:
12352202
EC Number:
232-928-9
NACRES:
NA.61
MDL number:
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Nombre del producto

ββ-Lactoglobulina from bovine milk, ≥90% (PAGE), lyophilized powder

biological source

bovine milk

assay

≥90% (PAGE)

form

lyophilized powder

technique(s)

ELISA: suitable

UniProt accession no.

storage temp.

2-8°C

Quality Level

Gene Information

bovine ... LGB(280838)

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Analysis Note

Puede no contener proteína de unión al folato; no recomendada para análisis de folatos.

Application

βLa β-lactoglobulina se utilizó en el análisis citológico para el diagnóstico de la hipersensibilidad alimentaria en pacientes con síndrome de intestino irritable.

Biochem/physiol Actions

Miembro de la familia de las lipocalinas, la βLg es una proteína pequeña de 162 aminoácidos con una masa molecular de ∼18 400 Da. Consta de un barril β de ocho cadenas (cadenas A-H) seguidas de una hélice α de tres vueltas y una cadena β final (cadena I) que forma parte de la interfaz de dimerización.

General description

La leche de las vacas lecheras contiene la proteína β-lactoglobulina (BLG). Aparece de manera natural en una serie de variantes genéticas, y las variantes bovinas más prevalentes son la BLG A y la BLG B.

Other Notes

Contiene β-lactoglobulinas A y B, que pueden aislarse mediante cromatografía.

Preparation Note

Purificada por cromatografía

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Certificados de análisis (COA)

Lot/Batch Number

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  1. How does the storage temperature relate to shipping conditions?

    The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.

  2. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  3. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  4. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  5. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  6. What is the molecular weight of Product L3908, β-Lactoglobulin from bovine milk?  

    Product L3908, β-Lactoglobulin from bovine milk, exists as a dimer of two peptides. Peptide A = 18,367, B = 18,281; the monomer is approximately 36,600.

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Sirpa Jylhä et al.
Journal of immunological methods, 350(1-2), 63-70 (2009-08-04)
Cow's milk allergy (CMA) is a common food allergy, especially among infants and young children. Approximately 85% of milk-allergic children outgrow their allergy by the age of three but the remaining 15% remain allergic. Bovine beta-lactoglobulin (BLG) is one of
Tilman Barz et al.
Journal of chromatography. A, 1217(26), 4267-4277 (2010-05-07)
In this work, parameters of the steric mass-formalism SMA are optimally ascertained for a reliable determination of the adsorption isotherms of beta-lactoglobulin A and B under non-isocratic conditions. For this purpose, static batch experiments are used in contrast to the
Lena Wartosch et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(12), 4056-4068 (2009-08-08)
Mutations in either ClC-7, a late endosomal/lysosomal member of the CLC family of chloride channels and transporters, or in its beta-subunit Ostm1 cause osteopetrosis and lysosomal storage disease in mice and humans. The severe phenotype of mice globally deleted for
Jonathan Vaneyck et al.
The Journal of biological chemistry, 296, 100358-100358 (2021-02-05)
The aggregation of the protein α-synuclein (aSyn) into amyloid fibrils in the human brain is associated with the development of several neurodegenerative diseases, including Parkinson's disease. The previously observed prion-like spreading of aSyn aggregation throughout the brain and the finding
Junzhen Zhong et al.
Food chemistry, 278, 491-496 (2018-12-26)
Previous work indicated that conformational changes of β-lactoglobulin (β-LG) induced by dynamic high pressure microfluidization (DHPM) was related to the increase of antigenicity. In this study, β-LG glycated with 1-kestose and combined with DHPM decreased the antigenicity of β-LG. The

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