L8397
ʟ-Leucinethiol
leucine aminopeptidase inhibitor, solid
Sinónimos:
Dithiobis(2-amino-4-methylpentane)
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Fórmula empírica (notación de Hill):
C12H28N2S2 · 2HCl
Número CAS:
Peso molecular:
337.42
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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Permítanos ayudarleNombre del producto
L-Leucinethiol, oxidized dihydrochloride, leucine aminopeptidase inhibitor
SMILES string
CC(C)C[C@H](N)CS
InChI
1S/C6H15NS/c1-5(2)3-6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/t6-/m0/s1
InChI key
GXEDNWSUKCJLLB-LURJTMIESA-N
form
solid
storage temp.
−20°C
Quality Level
Application
Upon reduction in vivo to L-leucinethiol, compound is a potent inhibitor of leucine aminopeptidase.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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T D Ocain et al.
Biochemical and biophysical research communications, 145(3), 1038-1042 (1987-06-30)
L-Lysinethiol was found to be an extremely potent inhibitor of aminopeptidase B (AP-B) with a Ki = 9.1 X 10(-10) M. L-leucinethiol was also a potent inhibitor of AP-B (kj = 1.3 X 10(-7) M), while the D-isomer was much
W W Chan
Biochemical and biophysical research communications, 116(1), 297-302 (1983-10-14)
L-leucinthiol (2-amino-4-methyl-1-pentanethiol) was designed as an inhibitor of leucine aminopeptidase by analogy with sulfhydryl inhibitors of other zinc-containing peptidases. It was synthesized from L-leucinol and shown to be a potent competitive inhibitor of the microsomal aminopeptidase from porcine kidney (Ki
Mirja Harms et al.
Scientific reports, 10(1), 16036-16036 (2020-10-01)
C-X-C chemokine receptor type 4 (CXCR4) is involved in several intractable disease processes, including HIV infection, cancer cell metastasis, leukemia cell progression, rheumatoid arthritis, asthma and pulmonary fibrosis. Thus, CXCR4 represents a promising drug target and several CXCR4 antagonizing agents
D S Pickering et al.
Archives of biochemistry and biophysics, 239(2), 368-374 (1985-06-01)
L-Leucinthiol, a synthetic derivative of mercaptoethylamine with a hydrophobic side chain, was recently reported to be a potent inhibitor of microsomal aminopeptidase. The structural features necessary for interaction of mercaptoamines with this enzyme have now been explored more systematically. Optimal
Kathrin Textoris-Taube et al.
European journal of immunology, 50(2), 270-283 (2019-11-16)
Dissecting the different steps of the processing and presentation of tumor-associated antigens is a key aspect of immunotherapies enabling to tackle the immune response evasion attempts of cancer cells. The immunodominant glycoprotein gp100209-217 epitope, which is liberated from the melanoma
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