M6524
Methoxamine hydrochloride
α1-adrenoceptor agonist
Sinónimos:
α-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol hydrochloride
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Fórmula empírica (notación de Hill):
C11H17NO3 · HCl
Número CAS:
Peso molecular:
247.72
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
200-499-7
MDL number:
Quality level:
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Permítanos ayudarleNombre del producto
Methoxamine hydrochloride,
Quality Level
InChI key
YGRFXPCHZBRUKP-UHFFFAOYSA-N
InChI
1S/C11H17NO3.ClH/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3;/h4-7,11,13H,12H2,1-3H3;1H
SMILES string
Cl[H].COc1ccc(OC)c(c1)C(O)C(C)N
storage temp.
2-8°C
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
Categorías relacionadas
Biochem/physiol Actions
α1-adrenoceptor agonist.
Features and Benefits
This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Robert H Thiele et al.
Anesthesia and analgesia, 113(2), 284-296 (2011-04-27)
Phenylephrine and methoxamine are direct-acting, predominantly α(1) adrenergic receptor (AR) agonists. To better understand their physiologic effects, we screened 463 articles on the basis of PubMed searches of "methoxamine" and "phenylephrine" (limited to human, randomized studies published in English), as
R H Lee et al.
Journal of neurophysiology, 81(5), 2164-2174 (1999-05-13)
Enhancement of bistability in spinal motoneurons in vivo by the noradrenergic alpha1 agonist methoxamine. Like many types of motoneurons, spinal motoneurons in the adult mammal can exhibit bistable behavior. This means that short periods of excitatory input can initiate long
Hideko Inaba et al.
Circulation journal : official journal of the Japanese Circulation Society, 75(1), 89-93 (2010-12-09)
Anesthesia sometimes suppresses ventricular tachyarrhythmias (VT) resistant to conventional pharmacological treatment. To know (1) whether deep anesthesia inhibits abnormal repolarization-related VT and (2) if α2-adrenoreceptor (AR) agonistic action is associated with the antiarrhythmic effect of anesthetics, the incidence of VT
Jiun-Jr Wang et al.
The Canadian journal of cardiology, 29(2), 243-253 (2012-05-25)
Using the reservoir-wave approach, we studied wave propagation, reflection, and re-reflection in the canine aorta with administrations of sodium nitroprusside (NP) and methoxamine (Mtx). In 8 anaesthetized dogs, excess pressures were calculated from pressure and flow measurements at 4 locations
Alain Frigon et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(15), 5579-5588 (2011-04-15)
Extra forces or torques are defined as forces or torques that are larger than would be expected from the input or stimuli, which can be mediated by properties intrinsic to motoneurons and/or to the muscle. The purpose of this study
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