N3136

Naltrexone hydrochloride

Name: Naltrexone hydrochloride
Brand: SIGMA

≥99% (HPLC), powder, opioid receptor antagonist

Sinónimos:

Naltrexone HCl

Iniciar sesión para ver los precios por organización y contrato.

Seleccione un Tamaño

Todas las fotos(2)

About This Item

Fórmula empírica (notación de Hill):

C₂₀H₂₃NO₄ · HCl

Número CAS:

16676-29-2

Peso molecular:

377.86

NACRES:

NA.77

PubChem Substance ID:

24278051

UNSPSC Code:

12352200

EC Number:

240-723-0

MDL number:

MFCD00069324

Beilstein/REAXYS Number:

3580333

Nombre del producto

Naltrexone hydrochloride,

InChI key

RHBRMCOKKKZVRY-ITLPAZOVSA-N

InChI

1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1

SMILES string

Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC6CC6

form

powder

originator

Novartis

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280)

¿Está buscando productos similares? Visita Guía de comparación de productos

Categorías relacionadas

Bioactive Small Molecules

Application

Naltrexone hydrochloride has been used:

as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model
to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model
in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Caenorhabditis elegans as a model system to identify therapeutics for alcohol use disorders

Katner SN, et al.

Behavioural Brain Research, 365, 7-16 (2019)

Ethanol-reinforced behaviour in the rat: effects of naltrexone.

P Bienkowski et al.

European journal of pharmacology, 374(3), 321-327 (1999-07-28)

It has been repeatedly reported that endogenous opioid pathways play an important role in ethanol drinking behaviour. In line with these findings, a non-selective opioid receptor antagonist, naltrexone, seems to reduce relapse rates in detoxified alcoholics. The aim of the

Early short-term PXT3003 combinational therapy delays disease onset in a transgenic rat model of Charcot-Marie-Tooth disease 1A (CMT1A)

Prukop T, et al.

Testing, 14(1), e0209752-e0209752 (2019)

Development and validation of a bioanalytical method for the simultaneous determination of heroin, its main metabolites, naloxone and naltrexone by LC-MS/MS in human plasma samples: Application to a clinical trial of oral administration of a heroin/naloxone formulation.

Raquel Moreno-Vicente et al.

Journal of pharmaceutical and biomedical analysis, 114, 105-112 (2015-06-04)

A bioanalytical method using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated for simultaneous quantification of heroin, its main metabolites and naloxone. In addition, naltrexone was detected qualitatively. This method was used to analyse human plasma samples from

Caenorhabditis elegans show preference for stimulants and potential as a model organism for medications screening

Engleman EA, et al.

Frontiers in Physiology, 9, 7-16 (2018)

Ver todos los artículos relacionados

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico