O2375
L-Ornithine monohydrochloride
≥99%
Sinónimos:
(S)-2,5-Diaminopentanoic acid monohydrochloride
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Fórmula empírica (notación de Hill):
C5H12N2O2 · HCl
Número CAS:
Peso molecular:
168.62
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
221-678-6
MDL number:
Beilstein/REAXYS Number:
3625847
Servicio técnico
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Permítanos ayudarleNombre del producto
L-Ornithine monohydrochloride, ≥99%
Quality Level
assay
≥99%
form
powder
impurities
ammonia and citrulline, essentially free
color
white
application(s)
cell analysis
SMILES string
Cl.NCCC[C@H](N)C(O)=O
InChI
1S/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H/t4-;/m0./s1
InChI key
GGTYBZJRPHEQDG-WCCKRBBISA-N
Application
L-Ornithine monohydrochloride has been used to study the blocking effect of L-ornithine on the transport system that carries L-arginine for the overproduction of nitric oxide during lipopolysaccharide induced endotoxemia in rat model. It has also been used in decarboxylation test of amino acids.
Biochem/physiol Actions
L-Ornithine is a product of arginase degradation and plays an important role in ammonia metabolism via the urea cycle. In mammals, ornithine serves as a precursor for polyamines and proline biosynthesis. Spermine synthesized from ornithine, is an abundant polyamine observed in tumors such as breast carcinomas. Administration of L-ornithine is known to improve subjective index of sleep quality. L-ornithine reduces the cortisol/DHEA-S (dehydroepiandrosterone) ratio, that is associated with stress. In mice, L-ornithine is found to affect the levels of plasma growth hormone, corticosterone and melatonin levels in mice.
Other Notes
Product of arginine degradation by arginase
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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L-Ornithine affects peripheral clock gene expression in mice
Takafumi Fukuda
Scientific Reports (2016)
THE EFFECT OF L-ORNITHINE ON THE INNER EAR OF RATS IN THE LIPOPOLYSACCHARIDE INDUCED ENDOTOXEMIA MODEL
Keal Gorur
Kulak Burun bo?az Ihtisas Dergisi : KBB = Journal of Ear, Nose, and Throat (2018)
Arginase Activity in Human Breast Cancer Cell Lines: N?-Hydroxy-l-arginine Selectively Inhibits Cell Proliferation and Induces Apoptosis in MDA-MB-468 Cells
Rajan Singh
Cancer Research, 60(12) (2000)