P5178

Phenobarbital sodium salt

Name: Phenobarbital sodium salt
Brand: SIGMA

GABAA receptor activator, powder

Sinónimos:

5-Ethyl-5-phenyl-2,4,6-trioxohexahydropyrimidine sodium salt, 5-Ethyl-5-phenylbarbituric acid sodium salt, Luminal sodium salt, Sodium 5-ethyl-5-phenylbarbiturate

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About This Item

Fórmula empírica (notación de Hill):

C₁₂H₁₁N₂NaO₃

Número CAS:

57-30-7

Peso molecular:

254.22

NACRES:

NA.77

PubChem Substance ID:

24898608

UNSPSC Code:

12352202

EC Number:

200-322-3

MDL number:

MFCD00036211

Beilstein/REAXYS Number:

3802044

Nombre del producto

Phenobarbital sodium salt,

InChI key

WRLGYAWRGXKSKG-UHFFFAOYSA-M

InChI

1S/C12H12N2O3.Na/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16;/h3-7H,2H2,1H3,(H2,13,14,15,16,17);/q;+1/p-1

SMILES string

[Na+].CCC1(C(=O)NC([O-])=NC1=O)c2ccccc2

form

powder

Quality Level

200

drug control

USDEA Schedule IV; Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet
kontrollierte Droge in Deutschland

solubility

H₂O: 1 g/mL
ethanol: 100 mg/mL

originator

Bayer

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Categorías relacionadas

Bioactive Small Molecules

Application

Phenobarbital sodium salt has been used:

to anesthetize mice for inducing ischemia-reperfusion injury
as a positive control for the activation of constitutive androstane receptor (CAR)
in bioluminescent yeast bioreporters (BLYAS) assay

Biochem/physiol Actions

Phenobarbital, a substituted barbituric acid is an antileptic drug and is not easily eliminated from circulation. It hyperpolarizes the synaptic neuronal membranes by favoring the activation of neuronal postsynaptic GABAA receptors by γ aminobutyric acid (GABA). Phenobarbital is also effective in treating neonatal seizures and status epilepticus.

Sedative; hypnotic; anticonvulsant; enhances GABAergic activity.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Dopamine and Norepinephrine Metabolism and GABAA Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H317,H351

pcodes

P202 - P261 - P264 - P280 - P301 + P310 - P302 + P352

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2 - Skin Sens. 1

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number

0000477396

0000469698

0000454058

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The effect of extracapsular injuries on growth and development of the mandible condyle: an experimental study in growing dogs.

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Oral surgery, oral medicine, oral pathology and oral radiology, 122(5), e131-e145 (2016-10-22)

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Enteral nutrition ameliorates the symptoms of Crohn's disease in mice via activating special pro-resolving mediators through innate lymphoid cells.

Di Zhao et al.

Innate immunity, 27(7-8), 533-542 (2021-11-19)

Crohn's disease activates the inflammatory reactions to induce intestinal disorders. Enteral nutrition (EN) could exert general immunomodulatory effects. Cecal ligation and perforation (CLP) surgery was utilized to establish Crohn's disease mice models. Survival analysis, hematoxylin-eosin staining, flow cytometry, ELISA, Western

Tisp40 deficiency attenuates renal ischemia reperfusion injury induced apoptosis of tubular epithelial cells

Qin C, et al.

Experimental Cell Research, 359(1), 138 -1144 (2017)

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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 42(6), 2492-2506 (2017-08-30)

Aberrant vascular smooth muscle cell (VSMC) proliferation and migration contribute to the development of vascular pathologies, such as atherosclerosis and post-angioplasty restenosis. The aim of this study was to determine whether miR-22-3p plays a role in regulating human artery vascular

Development and validation of the maximal electro-shock seizure model in dogs.

P R Territo et al.

Journal of veterinary pharmacology and therapeutics, 30(6), 508-515 (2007-11-10)

The development and validation of the maximal electro-shock (MES) model using phenobarbital (Pb) as the positive control is described. This approach builds on previous work in rodent model systems, and has been adapted to dogs as a tool for pharmaceutical

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Data Sheet - P5178

Datasheet

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