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Merck

P7936

Phosphocreatine disodium salt hydrate

≥97%

Sinónimos:

Creatine phosphate disodium salt, N-(Imino[phosphonoamino]methyl)-N-methylglycine

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About This Item

Fórmula lineal:
C4H8N3O5PNa2 · x H2O
Número CAS:
19333-65-4
Peso molecular:
255.08 (anhydrous basis)
NACRES:
NA.32
PubChem Substance ID:
24898895
UNSPSC Code:
12352204
EC Number:
213-074-6
MDL number:
MFCD00150191

Nombre del producto

Phosphocreatine disodium salt hydrate, ≥97%

InChI key

KZVYPOKBYRXZKS-UHFFFAOYSA-L

InChI

1S/C4H10N3O5P.2Na.H2O/c1-7(2-3(8)9)4(5)6-13(10,11)12;;;/h2H2,1H3,(H,8,9)(H4,5,6,10,11,12);;;1H2/q;2*+1;/p-2

SMILES string

O.[Na+].[Na+].CN(CC(O)=O)C(=N)NP([O-])([O-])=O

assay

≥97%

form

powder

impurities

≤0.02% free creatine

color

white

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

Quality Level

200

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Application

Phosphocreatine disodium salt hydrate has been used:
  • as a component: of Xenopus buffer (XB) buffer to remove the membrane-bound proteins
  • of M5+ buffer to perform polarized total internal reflection fluorescence (polTIRF) experiments
  • of ATP regenerating system for 7-nitro-2-1,3-benzoxadiazol-4-yl phospholipid(NBD-PL) translocation assay

Biochem/physiol Actions

Phosphocreatine disodium salt hydrate is useful to study nasopharyngeal carcinoma cells and induced temporary cardiac arrest. It also evaluate the effects of adenosine A(2A) receptor modulation in the nucleus accumbens on cocaine seeking in rats.
Phosphocreatine is widely known for its quickest form of regeneration using enzyme creatine kinase. It functions as a temporal energy buffer. Phosphocreatine is present in muscle tissues and plays a major role in maintaining energy homeostasis in muscle cells.
Phosphocreatine, a high-energy phosphate reservoir in vertebrate and some invertebrate muscles, provides phosphate for ADP-ATP conversion.

Preparation Note

Prepared enzymatically

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000518137
0000518139
0000518138
0000518138
0000518137

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Cyril Bernis et al.
Methods in cell biology, 122, 165-191 (2014-05-27)
The large and complex eukaryotic nucleus is the arbiter of DNA replication, RNA transcription, splicing, and ribosome assembly. With the advent of in vitro nuclear reconstitution extracts derived from Xenopus eggs in the 1980s, it became possible to assemble multiple
Protective effects of a magnesium magnetic isotope (Mg(25) )-exchanging nanoparticle ((25) MgPMC(16) ) on mitochondrial functional disorders in esmolol-induced cardiac arrest in rats
Adeli, S., et al.
Auton. Autocoid Pharmacol., 32, 1-7 (2012)
Casey E O'Neill et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 37(5), 1245-1256 (2011-12-16)
Repeated cocaine administration enhances dopamine D(2) receptor sensitivity in the mesolimbic dopamine system, which contributes to drug relapse. Adenosine A(2A) receptors are colocalized with D(2) receptors on nucleus accumbens (NAc) medium spiny neurons where they antagonize D(2) receptor activity. Thus
Lucas Guimarães-Ferreira
Einstein (Sao Paulo, Brazil), 12(1), 126-131 (2014-04-15)
Adenosine triphosphate is the present energy currency in the body, and is used in various cellular and indispensable processes for the maintenance of cell homeostasis. The regeneration mechanisms of adenosine triphosphate, from the product of its hydrolysis - adenosine diphosphate
John F Beausang et al.
Biophysical journal, 104(6), 1263-1273 (2013-03-27)
Myosin V is biomolecular motor with two actin-binding domains (heads) that take multiple steps along actin by a hand-over-hand mechanism. We used high-speed polarized total internal reflection fluorescence (polTIRF) microscopy to study the structural dynamics of single myosin V molecules
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